xRead - Nasal Obstruction (September 2024) Full Articles

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425

Orlandi et al.

Probiotic treated grouphad

reduction in

number and

duration of RS episodes

No improvement of sinonasal QoL

scores with oral probiotics

significant change

in SNOT-22 scores, microbiologic flora, or local

inflammatory markers

Duration 6 months therapy Reduction in

frequency and

time to recurrence of RS episodes in

the treated group

TABLE IX-37 Evidence for CRS management with probiotics Authors Year LOE Type of Study Patient Groups Clinical Endpoint Conclusions Martensson 1195 2017 2 Double-blind randomized, crossover, sham-controlled trial 20 patients with CRSsNP 14/20 patients had previous ESS 1. mixture of 9 lactobacilli and 4 bifidobacteria (Honeybee microbiome) topical nasal spray 2. Sham solution SNOT-22, Microbiome, Inflammatory proteins in nasal lavage fluid Duration 14 days No statistically

SNOT20 Duration 4 weeks

Mean duration of RS episodes,

Frequency of RS episodes

Time to recurrent ABRS; Relative risk of ABRS;

Severity of ABRS;

Use of antibiotic therapy; side

effects; laboratory tests

immunostimulant (3 × 30

1. 8 weeks of oral probiotic Enterococcus faecalis in suspension

157 patients with chronic recurrent RS 1. Oral bacterial +

After 4 weeks of wash out, the subjects were crossed over to the other arm 77 patients with CRS 1. oral probiotic Lactobacillus rhamnosus (500 million

drops/day), comprised of cells and autolysate of human Enterococcus faecalis bacteria 2. Placebo

active cells/tablet twice daily)

204 children with RARS (4-6 episodes/yr) Standard RS treatment

(amoxicillin 7 days, nasal anticongestants TID) followed by:

2. oral placebo twice daily

2. no probiotic treatment

double-blind

placebo-controlled trial

Kitz 1193 2012 3 Prospective phase IV controlled trial (not randomized)

placebo-controlled trial

Mukerji 1194 2009 2 Randomized

Habermann 1192 2002 2 Double-blind