xRead - Nasal Obstruction (September 2024) Full Articles

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430

International consensus statement on rhinosinusitis

MH for 12-week vs saline: cytokines IL-6, IL-8, MCP-1, and MIP-1 β were

(Continues)

significantly increased and IL-13 was significantly reduced

TABLE IX-40 Evidence for CRS management with manuka honey Authors Year LOE Type of Study Patient Groups Clinical Endpoint Outcomes Ooi 1232 2019 2 Single-blind RCT 25 patients with CRS who had previous sinus surgery Treated with - 16.5%MH + 1.3mg/mL MGO sinonasal rinses twice daily and concurrent 10 days placebo tablets Safety observation: UPSIT and AE reporting; Efficacy observation: Lund-Kennedy score, VAS symptom score, SNOT-22 Duration 14 days Safety observation: UPSIT and AE reporting Efficacy observation: Lund-Kennedy score, VAS symptom score, SNOT-22 symptom score

Safety: no AE or changes in UPSIT

mg/mL MGO sinonasal

rinses alone is safe but not

superior to culture directed oral antibiotics and saline rinses twice daily

Both MH and SAL improved outcomes

No statistically significant difference in SNOT-22

scores, Lund-Kennedy endoscopic scores

statistically better with MH in patients who did not receive oral antibiotics/steroids

MH augmented with 1.3

Duration 30 days

Culture negativity was

Cytokine expression in tissue biopsies.

Endoscopic score;

Culture negativity

SNOT22;

Lund-Kennedy

1. 10% (vol/vol) MH irrigation ½ bottle twice daily 2. Saline sinus irrigation ½ bottle twice daily

CRSwNP); biopsies taken: during ESS; at 5 and at 12 weeks

MH sinus irrigations (5-7%) twice daily for 3 months

Saline irrigations in control patients

- Saline sinonasal rinses twice daily and concurrent 10 days culture-directed antibiotics therapy

Lee 1230 2017 2 Single-blind RCT 42 patients with CRS who had previous sinus surgery treated with daily

46 patients (CRSsNP or

control trial

Manji 1231 2019 2 Randomized