xRead - Nasal Obstruction (September 2024) Full Articles

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436

International consensus statement on rhinosinusitis

Improvement in symptoms, Reduction in size of polyps compared to controls,

Reduction in objective nasal resistance.

TABLE IX-43 Evidence for CRS management with capsaicin Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions Zheng 1255 2000 2 Randomized, placebo controlled Cotton pellet soaked in capsaicin (3 × 10 − 6 mol in 70% ethanol) in middle meatus post-limited sinus surgery, Placebo (70% ethanol alone) with same Subjective evaluation of nasal obstruction and rhinorrhea by visual analog scale, Improvement in subjective NAR and endoscopy staging of polyps in treatment group. No difference in rhinorrhea. Filiaci 1256 1996 3 Double blind, placebo

scores, and endoscopy scores. No change in ECP levels.

Improved NSAV, subjective

Endoscopy staging of polyps. Evaluations performed at 1 week preop and monthly postop x 9 months.

Nasal resistance by anterior rhinomanometry

Specific nasal provocation testing with cold water and

rhinomanometric assessment of NAR. Evaluations performed

before and after each treatment and at 1 and 3 months post-treatment.

ECP levels in nasal lavage. All reviewed pre- and post-treatment and weekly x 4 weeks.

Symptom questionnaire, Endoscopy scores,

Nose/sinus air volume (NSAV), Subjective scores, Endoscopy scores,

Topical capsaicin 0.5 mL (30 μ mol/L) x 3 days, then100 μ mol/L on days

Topical capsaicin (0.1 mL of 30 μ mol/L) once weekly x 5 weeks, Placebo

application method.

4 and 5 in patients with NP.

(0.1 mL of physiological solution alone) with

same application method

controlled

Baudoin 1257 2000 4 Prospective, case series