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Orlandi et al.

Rate of atopy by SPT SPT Yes Twice as many CRSwNP with sensitivity to dust and O. europaea than controls.

Rate of atopy by SPT SPT Yes Higher incidence & more rapid response to Candida

(Continues)

than controls, but similar to CRSsNP. CRSwNP had higher number of sensitivities.

and increase positivity to at least 1 mold.

Rate of atopy by SPT SPT Yes CRSwNP were 6 times more likely to have positive antigen sensitivity than healthy controls.

Rates of sensitivity to specific antigens bySPT SPT Yes Higher prevalence of Candida and dust mite sensitivity in CRSwNP than without polyps.

Higher total IgE in eNP compared to nNP and controls.

among nNP compared to eNP and controls.

Possible Higher atopy in CRSwNP

Higher rates of sensitivity

Association between Allergy and CRSwNP Conclusions

Allergy

Testing

Method

Rates of sensitivity to inhalant allergens by invitro methods. Total IgE.

Rate of atopy by SPT Number of positive tests

TABLE X-4 Evidence for inhalant allergy as a contributing factor for CRSwNP Study Year LOE Study Design Study Groups Clinical Endpoint Xu 1392 2015 3 Prospective case series Eosinophilic CRSwNP Non-eosinophilic CRSwNP Controls Tan 1380 2011 3 Prosective case control CRSwNP CRSsNP Munoz 1383 2009 3 Prosective case control CRSwNP

Patients with known allergy CRSwNP

Healthy Control CRSwNP

CRSsNP

Healthy Control

CRSwNP

Asero 1400 2001 3 Prosective case control

Asero 1382 2000 3 Prosective case control

Pumhirun 1384 1999 3 Prosective case control