xRead - Nasal Obstruction (September 2024) Full Articles

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539

Orlandi et al.

Culture directed therapy improved long term endoscopy scores

compared to empiric

therapy but not short-term endoscopy scores or short

and long term QoL scores.

TABLE XI-1 Evidence for management of AECRS Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions Sabino 211 2017 2 RCT Amoxicillin-clavulanate for 14 days (21) Placebo (11) SSA Lund-Kennedy score Nasal endoscopy Culture results SNOT-22 Amoxicillin-clavulanate did not change short term evolution of symptoms or QoL scores compared to placebo. antibiotic (61)

antibiotics results in a

decrease QoL at 3 months followup.

SNOT-22 Culture inappropriate

Lund-Kennedy score short term ( < 1

SNOT-22 short term ( < 1 month) and long term (1-6 months)

month) and long

term (1-6 months);

1. Culture inappropriate antibiotics (27)

2. Culture appropriate after adjustment (19)

3. Culture appropriate antibiotics (66)

Empiric antibiotics (61)

antibiotics

4. Undetermined (264)

Zhang 1762 2014 4 Retrospective review Post ESS 14 days of

Yan 1761 2018 4 Retrospective review Culture-directed