xRead - Nasal Obstruction (September 2024) Full Articles

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552

International consensus statement on rhinosinusitis

(Continues)

Preemptive administration of piroxicam- β -cyclodextrin effectively

reduces analgesic consumption, with 40 mg of the drug more effective than the 20-mg dose, without side effects. When given with intraoperative local infiltration with 1% mepivacaine,

parecoxib is as effective in treating early postoperative pain as ketorolac.

The use of nonopioid analgesics after ESS may provide similar pain control to oral opioids.

When given with intraoperative local infiltration with 1% mepivacaine, parecoxib is not superior to proparacetamol.

Preoperative administration of rofecoxib provides a significant analgesic benefit for intraoperative and postoperative pain

relief and decreased the need for opioids after nasal surgery.

Study Year LOE Design Study Groups Clinical Endpoint Conclusions Keles 1882 2010 2 Prospective, DB RCT Piroxicam- β -cyclodextrin 20 mg PO (25)

Postoperative VAS at 10, 20, and 30 minutes, and 1, 2, 3, 4, 5, 6, 12, 24 hours

Postoperative VAS at PODs 1, 2, 3, and4 Requirement for rescue analgesia Adverse events

minutes, and 1, 2, 4, 6, and 24hours

Postoperative VAS at 10, 20, and 30 minutes, and 1, 2, 3, 4, 5, 6, 12, 24 hours

minutes and 2, 4, 6, 12, and 24hours

Intraoperative VRS at 5, 15, 30, 45, and 60 minutes

Morphine consumption

Patient satisfaction

Postoperative VAS at 30

Morphine consumption

Morphine consumption.

Postoperative VAS at 30

Total fentanyl consumption

Time to first analgesic need

Piroxicam- β -cyclodextrin

dosed intraoperatively and q8 hours post-op. Parecoxib 40 mg IV (25)

Hydrocodone/acetaminophen 7.5/750 mg PO (14) Rofecoxib 50 mg PO (14)

Parecoxib 40 mg IV (25)

Ketorolac 30 mg IV (25)

40 mg PO (25)

Placebo PO (25)

Proparacetamol 2 gm IV (25)

Rofecoxib 50 mg PO (30) Placebo PO (30)

Leykin 1883 2008 2 Prospective, DB RCT

Church 1885 2006 2 Prospective, DB RCT

Leykin 1884 2008 2 Prospective, DB RCT

Turan 1866 2002 2 Prospective, DB RCT

TABLE XII-4 (Continued)