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Orlandi et al.
because outcome metrics are
not clearly defined or blinded from surgeon/reviewer
CT has higher sensitivity and specificity than plain films.
TABLE XIII-6 Evidence for the diagnosis of pediatric CRS Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions Brietzke 2341 2014 1 N/A N/A N/A Clinical consensus statement Fokkens 31 2012 1 N/A N/A N/A Clinical consensus statement Bhattacharyya 2345 2004 3 Prospective cohorts 1. CTs of children with PCRS undergoing ESS Lund-Mackay Score PCRS mean LM score 10.4; control mean LM score 2.8. LM cutoff of 5 has high McAlister 2343 1989 3 Prospective
sensitivity and specificity.
because of poor control group matching (nasal endoscopy
findings not quantified). This limitation does not affect the data cited in text above.
Presence of inflammation Downgraded from Level 3
Downgraded from Level 3
Radiographic evidence of inflammation in the sinuses Prevalence of
nasal obstruction, epistaxis
Halitosis, cough, facial pain, rhinorrhea,
1. Plain films of children who underwent ESS for CRS
2. CT scans of children who underwent ESS for CRS 3. Intraop findings
1. Plain films of children with chronic sinus symptoms
CTs of children for non-RS diagnosis
evidence of inflammation on nasal endoscopy
47 children with CRS symptoms, normal nasal endoscopy
CT scans of same children
Leo 2342 2015 4 Cohort study 228 children with CRS and
observational
cohort study
Lazar 2344 1992 4 Retrospective cohort
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