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from normal bone. Int Forum Allergy Rhinol . 2015;5(2):124 131. 670. Khalmuratova R, Shin HW, Kim DW, Park JW. Inter leukin (IL)-13 and IL-17A contribute to neo-osteogenesis in chronic rhinosinusitis by inducing RUNX2. EBioMedicine . 2019;46:330-341. 671. Gunel C, Bleier BS, Bozkurt G, Eliyatkin N. Microarray analy sis of the genes associated with osteitis in chronic rhinosinusi tis. Laryngoscope . 2017;127(3):E85-E90. 672. Wu D, Nocera AL, Mueller SK, Finn K, Libermann TA, Bleier BS. Osteitis is associated with dysregulated pro osteoblastic activity in patients with nasal polyps. Laryngo scope . 2019;129(3):E102-E109. 673. Kong IG, Kim DK, Eun KM, et al. Receptor activator of nuclear factor κ B ligand is a biomarker for osteitis of chronic rhinosi nusitis. Int Forum Allergy Rhinol . 2020;10(3):364-373. 674. Antunes MB, Feldman MD, Cohen NA, Chiu AG. Dose dependent effects of topical tobramycin in an animal model of Pseudomonas sinusitis. AmJRhinol . 2007;21(4):423-427. 675. Richter JE, Rubenstein JH. Presentation and epidemiol ogy of gastroesophageal reflux disease. Gastroenterology . 2018;154(2):267-276. 676. DelGaudio JM. Direct nasopharyngeal reflux of gastric acid is a contributing factor in refractory chronic rhinosinusitis. Laryngoscope . 2005;115(6):946-957. 677. Pincus RL, Kim HH, Silvers S, Gold S. A study of the link between gastric reflux and chronic sinusitis in adults. EarNose Throat J . 2006;85(3):174-178. 678. DiBaise JK, Olusola BF, Huerter JV, Quigley EM. Role of GERD in chronic resistant sinusitis: a prospective, open label, pilot trial. Am J Gastroenterol . 2002;97(4):843-850. 679. Anzić SA, Turkalj M, Župan A, Labor M, Plavec D, Baudoin T. Eight weeks of omeprazole 20 mg significantly reduces both laryngopharyngeal reflux and comorbid chronic rhinosinusi tis signs and symptoms: randomised, double-blind, placebo controlled trial. Clin Otolaryngol . 2018;43(2):496-501. 680. Vaezi MF, Hagaman DD, Slaughter JC, et al. Proton pump inhibitor therapy improves symptoms in postnasal drainage. Gastroenterology . 2010;139(6):1887-1893.e1881; quiz e1811. 681. Leason SR, Barham HP, Oakley G, et al. Association of gastro-oesophageal reflux and chronic rhinosinusitis: system atic review and meta-analysis. Rhinology . 2017;55(1):3-16. 682. Ozmen S, Yucel OT, Sinici I, et al. Nasal pepsin assay and pH monitoring in chronic rhinosinusitis. Laryngoscope . 2008;118(5):890-894. 683. Jecker P, Orloff LA, Wohlfeil M, Mann WJ. Gastroesophageal reflux disease (GERD), extraesophageal reflux (EER) and recurrent chronic rhinosinusitis. Eur Arch Otorhinolaryngol . 2006;263(7):664-667. 684. Ulualp SO, Toohill RJ, Hoffmann R, Shaker R. Possible rela tionship of gastroesophagopharyngeal acid reflux with patho genesis of chronic sinusitis. AmJRhinol . 1999;13(3):197-202. 685. Katle E-J, Hatlebakk JG, Grimstad T, Kvaløy JT, Steinsvåg SK. Gastro-oesophageal reflux in patients with chronic rhino sinusitis investigated with multichannel impedance-pH mon itoring. Rhinology . 2017;55(1):27. 686. Loehrl TA, Smith TL, Darling RJ, et al. Autonomic dysfunction, vasomotor rhinitis, and extraesophageal

rhinosinusitis and healthy controls. Int Forum Allergy Rhinol . 2012;2(2):116-121. 653. Georgalas C. Osteitis and paranasal sinus inflammation: what we know and what we do not. Curr Opin Otolaryngol Head NeckSurg . 2013;21(1):45-49. 654. Emre IE, Celebi I, Ercan I. The radiologic evaluation of osteitis type and formation in chronic rhinosinusitis with and without nasal polyposis. Am J Rhinol Allergy . 2015;29(6):e201-e204. 655. Catalano PJ, Dolan R, Romanow J, Payne SC, Silverman M. Correlation of bone SPECT scintigraphy with histopathology of the ethmoid bulla: preliminary investigation. Ann Otol Rhi nol Laryngol . 2007;116(9):647-652. 656. Saylam G, Gorgulu O, Korkmaz H, Dursun E, Ortapamuk H, Eryilmaz A. Do single-photon emission computerized tomog raphy findings predict severity of chronic rhinosinusitis: a pilot study. Am J Rhinol Allergy . 2009;23(2):172-176. 657. Georgalas C, Videler W, Freling N, Fokkens W. Global Osteitis Scoring Scale and chronic rhinosinusitis: a marker of revision surgery. Clin Otolaryngol . 2010;35(6):455-461. 658. Kim HY, Dhong HJ, Lee HJ, et al. Hyperostosis may affect prognosis after primary endoscopic sinus surgery for chronic rhinosinusitis. Otolaryngol Head Neck Surg . 2006;135(1):94-99. 659. Sacks PL, Snidvongs K, Rom D, Earls P, Sacks R, Harvey RJ. The impact of neo-osteogenesis on disease control in chronic rhinosinusitis after primary surgery. Int Forum Allergy Rhinol . 2013;3(10):823-827. 660. Cho SH, Shin KS, Lee YS, et al. Impact of chronic rhinosinusi tis and endoscopic sinus surgery on bone remodeling of the paranasal sinuses. AmJRhinol . 2008;22(5):537-541. 661. Snidvongs K, McLachlan R, Sacks R, Earls P, Harvey RJ. Cor relation of the Kennedy Osteitis Score to clinico-histologic features of chronic rhinosinusitis. Int Forum Allergy Rhinol . 2013;3(5):369-375. 662. Huang Z, Hajjij A, Li G, Nayak JV, Zhou B, Hwang PH. Clini cal predictors of neo-osteogenesis in patients with chronic rhi nosinusitis. Int Forum Allergy Rhinol . 2015;5(4):303-309. 663. Zhao YC, Wormald PJ. Biofilm and osteitis in refrac tory chronic rhinosinusitis. Otolaryngol Clin North Am . 2017;50(1):49-60. 664. Dong D, Yulin Z, Xiao W, et al. Correlation between bacterial biofilms and osteitis in patients with chronic rhinosinusitis. Laryngoscope . 2014;124(5):1071-1077. 665. Khalid AN, Hunt J, Perloff JR, Kennedy DW. The role of bone in chronic rhinosinusitis. Laryngoscope . 2002;112(11):1951-1957. 666. Karempelis P, Karp E, Rubin N, Hunter R, Dunitz J, Boyer H. Risk factors for neo-osteogenesis in cystic fibrosis and non cystic fibrosis chronic rhinosinusitis. Int Forum Allergy Rhinol . 2019;10(4):505-510. 667. Wang M, Ye T, Liang N, et al. Differing roles for TGF beta/Smad signaling in osteitis in chronic rhinosinusitis with and without nasal polyps. Am J Rhinol Allergy . 2015;29(5):e152 159. 668. Gunel C, Feldman RE, Bleier BS. Osteitis is associated with P glycoprotein overexpression in patients with chronic sinusi tis without nasal polyps. Am J Rhinol Allergy . 2014;28(2):99 102. 669. Stevens PR, Tessema B, Brown SM, Parham K, Gronowicz G. Chronic rhinosinusitis osteoblasts differ in cellular properties