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vitamin D3 deficiencies in patients with chronic rhinosinusi tis. J Allergy Clin Immunol . 2014;134(2):342-349. 720. Wang LF, Lee CH, Chien CY, Chen JY, Chiang FY, Tai CF. Serum 25-hydroxyvitamin D levels are lower in chronic rhi nosinusitis with nasal polyposis and are correlated with dis ease severity in Taiwanese patients. Am J Rhinol Allergy . 2013;27(6):e162-e165. 721. Brot C, Jorgensen NR, Sorensen OH. The influence of smoking on vitamin D status and calcium metabolism. Eur J Clin Nutr . 1999;53(12):920-926. 722. Pinto JM, Schneider J, Perez R, DeTineo M, Baroody FM, Naclerio RM. Serum 25-hydroxyvitamin D levels are lower in urban African American subjects with chronic rhinosinusitis. J Allergy Clin Immunol . 2008;122(2):415-417. 723. Sultan B, Ramanathan M, Jr., Lee J, May L, Lane AP. Sinonasal epithelial cells synthesize active vitamin D, aug menting host innate immune function. Int Forum Allergy Rhi nol . 2013;3(1):26-30. 724. Christensen JM, Cheng J, Earls P, et al. Vitamin D pathway regulatory genes encoding 1 α -hydroxylase and 24-hydroxylase are dysregulated in sinonasal tissue during chronic rhinosi nusitis. Int Forum Allergy Rhinol . 2017;7(2):169-176. 725. Faghih Habibi A, Gerami H, Banan R, et al. Serum 25-hydroxy vitamin D in chronic rhinosinusitis with and without nasal polyposis: a case-control study in Northern Iran. Iranian J Otorhinolaryngol . 2019;31(1):19-24. 726. Sansoni ER, Sautter NB, Mace JC, et al. Vitamin D3 as a novel regulator of basic fibroblast growth factor in chronic rhinosinusitis with nasal polyposis. Int Forum Allergy Rhinol . 2015;5(3):191-196. 727. Sugimoto I, Hirakawa K, Ishino T, Takeno S, Yajin K. Vita min D3, vitamin K2, and warfarin regulate bone metabolism in human paranasal sinus bones. Rhinology . 2007;45(3):208 213. 728. el-Fiky LM, Khamis N, Mostafa Bel D, Adly AM. Staphylococ cal infection and toxin production in chronic rhinosinusitis. Am J Rhinol Allergy . 2009;23(3):264-267. 729. Foreman A, Holtappels G, Psaltis AJ, et al. Adaptive immune responses in Staphylococcus aureus biofilm-associated chronic rhinosinusitis. Allergy . 2011;66(11):1449-1456. 730. Cui XY, Miao JL, Lu HQ, et al. Serum levels of specific IgE to Staphylococcus aureus enterotoxins in patients with chronic rhinosinusitis. Exp Therap Med . 2015;9(4):1523-1527. 731. Delemarre T, Holtappels G, De Ruyck N, et al. Type 2 inflammation in chronic rhinosinusitis without nasal polyps: another relevant endotype. J Allergy Clin Immunol . 2020;146(2):337-343.e336. 732. Yan M, Pamp SJ, Fukuyama J, et al. Nasal microenviron ments and interspecific interactions influence nasal micro biota complexity and S. aureus carriage. Cell Host Microbe . 2013;14(6):631-640. 733. Biswas K, Hoggard M, Jain R, Taylor MW, Douglas RG. The nasal microbiota in health and disease: variation within and between subjects. Front Microbiol . 2015;9:134. 734. Frank DN, Feazel LM, Bessesen MT, Price CS, Janoff EN, Pace NR. The human nasal microbiota and Staphylococcus aureus carriage. PloSone . 2010;5(5):e10598.