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positions after frontal sinusotomy. Eur Arch Otorhinolaryngol . 2020;277(5):1361-1368. 1262. Barham HP, Ramakrishnan VR, Knisely A, et al. Frontal sinus surgery and sinus distribution of nasal irrigation. Int Forum Allergy Rhinol . 2016;6(3):238-242. 1263. Bhalla V, Sykes KJ, Villwock JA, Beahm DD, McClurg SW, Chiu AG. Draf IIB with superior septectomy: finding the “mid dle ground”. Int Forum Allergy Rhinol . 2019;9(3):281-285. 1264. Harvey RJ, Debnath N, Srubiski A, Bleier B, Schlosser RJ. Fluid residuals and drug exposure in nasal irrigation. Oto laryngol Head Neck Surg . 2009;141(6):757-761. 1265. Hwang PH, Woo RJ, Fong KJ. Intranasal deposition of neb ulized saline: a radionuclide distribution study. AmJ Rhinol . 2006;20(3):255-261. 1266. Manes RP, Tong L, Batra PS. Prospective evaluation of aerosol delivery by a powered nasal nebulizer in the cadaver model. Int Forum Allergy Rhinol . 2011;1(5):366-371. 1267. Djupesland PG, Messina JC, Mahmoud RA. Exhalation deliv ery systems (EDS) greatly increase topical delivery to tar get sites for chronic rhinosinusitis (CRS) compared to nasal sprays or pressurized MDIs (pMDI). J Allergy Clin Immunol . 2018;141(2):AB274. 1268. Djupesland PG, Messina JC, Palmer JN. Deposition of drugs in the nose and sinuses with an exhalation delivery system vs conventional nasal spray or high-volume irrigation in Draf II/III post-surgical anatomy. Rhinology . 2020;58(2):175-183. 1269. Möller W, Schuschnig U, Celik G, et al. Topical drug deliv ery in chronic rhinosinusitis patients before and after sinus surgery using pulsating aerosols. PloSOne . 2013;8(9):e74991. 1270. Abadie WM, McMains KC, Weitzel EK. Irrigation penetration of nasal delivery systems: a cadaver study. Int Forum Allergy Rhinol . 2011;1(1):46-49. 1271. Kalish L, Snidvongs K, Sivasubramaniam R, Cope D, Harvey RJ. Topical steroids for nasal polyps. Cochrane Database Syst Rev . 2012;12:CD006549. 1272. Farzal Z, Basu S, Mamdani M, et al. Comparative analysis of nebulizer and "line of sight" spray drug delivery to chronic rhi nosinusitis target sites. J Aerosol Med Pulm Drug Deliv . 2019. 1273. Poletti SC, Batashev I, Reden J, Hummel T. Olfaction in chronic rhinosinusitis: comparing two different endonasal steroid application methods. Eur Arch Otorhinolaryngol . 2017;274(3):1431-1435. 1274. Djupesland PG, Messina J, Mahmoud R. New exhalation delivery systems (EDS) enhance topical steroid delivery in chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol . 2017;139(2):AB65. 1275. Shah SA, Berger RL, McDermott J, et al. Regional deposition of mometasone furoate nasal spray suspension in humans. Allergy Asthma Proc . 2015;36(1):48–57. 1276. Reychler G, Colbrant C, Huart C, et al. Effect of three-drug delivery modalities on olfactory function in chronic sinusitis. Laryngoscope . 2015;125(3):549-555. 1277. Roxbury CR, Tang D, Shah J, McBride J, Woodard TD, Sind wani R. Size of septectomy does not affect distribution of nasal irrigation after endoscopic modified Lothrop procedure. Int Forum Allergy Rhinol . 2018;8(10):1127-1131. 1278. Craig JR, Palmer JN, Zhao K. Computational fluid dynamic modeling of nose-to-ceiling head positioning for sphenoid sinus irrigation. Int Forum Allergy Rhinol . 2017;7(5):474-479.

1244. Derry S, Rice AS, Cole P, Tan T, Moore RA. Topical capsaicin (high concentration) for chronic neuropathic pain in adults. Cochrane Database Syst Rev . 2017;1(1):CD007393. 1245. Bernstein JE, Parish LC, Rapaport M, Rosenbaum MM, Roenigk HH, Jr. Effects of topically applied capsaicin on moderate and severe psoriasis vulgaris. J Am Acad Dermatol . 1986;15(3):504-507. 1246. Ellis CN, Berberian B, Sulica VI, et al. A double-blind evalua tion of topical capsaicin in pruritic psoriasis. J Am Acad Der matol . 1993;29(3):438-442. 1247. Gevorgyan A, Segboer C, Gorissen R, van Drunen CM, Fokkens W. Capsaicin for non-allergic rhinitis. Cochrane Database Syst Rev . 2015;(7):CD010591. 1248. Lundblad L. Protective reflexes and vascular effects in the nasal mucosa elicited by activation of capsaicin-sensitive sub stance P-immunoreactive trigeminal neurons. Acta Physiol Scand Suppl . 1984;529:1-42. 1249. Stjarne P, Lundblad L, Anggard A, Hokfelt T, Lundberg JM. Tachykinins and calcitonin gene-related peptide: co-existence in sensory nerves of the nasal mucosa and effects on blood flow. Cell Tissue Res . 1989;256(3):439-446. 1250. Stjarne P. Sensory and motor reflex control of nasal mucosal blood flow and secretion; clinical implications in non-allergic nasal hyperreactivity. Acta Physiol Scand Suppl . 1991;600:1-64. 1251. Stjarne P, Lundblad L, Anggard A, Lundberg JM. Local cap saicin treatment of the nasal mucosa reduces symptoms in patients with nonallergic nasal hyperreactivity. Am J Rhinol Allergy . 1991;5(4):145-151. 1252. Lacroix JS, Buvelot JM, Polla BS, Lundberg JM. Improvement of symptoms of non-allergic chronic rhinitis by local treat ment with capsaicin. Clin Exp Allergy . 1991;21(5):595-600. 1253. Lacroix JS, Kurt AM, Pochon N, Bretton C, Lundberg JM, Deshusses J. Neutral endopeptidase activity and concentra tion of sensory neuropeptide in the human nasal mucosa. Eur Arch Otorhinolaryngol . 1995;252(8):465-468. 1254. Gungor A, Baroody FM, Naclerio RM, White SR, Corey JP. Decreased neuropeptide release may play a role in the pathogenesis of nasal polyps. Otolaryngol Head Neck Surg . 1999;121(5):585-590. 1255. Zheng C, Wang Z, Lacroix JS. Effect of intranasal treatment with capsaicin on the recurrence of polyps after polypectomy and ethmoidectomy. Acta Otolaryngol . 2000;120(1):62-66. 1256. Filiaci F, Zambetti G, Luce M, Ciofalo A. Local treatment of nasal polyposis with capsaicin: preliminary findings. Allergol Immunopathol (Madr) . 1996;24(1):13-18. 1257. Baudoin T, Kalogjera L, Hat J. Capsaicin significantly reduces sinonasal polyps. Acta Otolaryngol . 2000;120(2):307-311. 1258. Orlandi RR, Smith TL, Marple BF, et al. Update on evidence based reviews with recommendations in adult chronic rhinos inusitis. Int Forum Allergy Rhinol . 2014;4(Suppl 1):S1-S15. 1259. Thomas WW, 3rd, Harvey RJ, Rudmik L, Hwang PH, Schlosser RJ. Distribution of topical agents to the paranasal sinuses: an evidence-based review with recommendations. Int Forum Allergy Rhinol . 2013;3(9):691-703. 1260. Griggs ZH, Williams AM, Craig JR. Head and bottle angles achieved by patients during high-volume sinonasal irriga tions. Am J Rhinol Allergy . 2019;33(3):302-309. 1261. Wu Y-X, Wang M, Li H, et al. Efficacy and safety of delivery of topical medication on to the frontal sinus at different head