xRead - Olfactory Disorders (September 2023)

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437

PATEL et al.

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point

Topic

Study

Year LOE

Conclusions

Ross et al 727

Premortem B-SIT scores lower in cases with LB Smell is only significant

B-SIT Cognitive

2006 4

Case

17 brains with LB 147brains without LB

control

Abilities Screening Instrument and demographics

measure that differs between brain types

Bohnen et al 728

2007 4

Case

27PD 27HCs

UPSIT R Dopamine

UPSIT R scores lower in PD 3 odors identified with an accuracy of > 0.75 for diagnosing PD Significant correlations were present between the test scores and striatal DAT activity on PET imaging 9 of 11 (82%) mutation carriers exhibited impaired smell function The 2 who scored normal were from the same family Sensory complaints and daytime somnolence were present in 8 and 7 of these G2019S-positive patients, respectively B-SIT scores lower in PD Scores did not correlate with disease duration, stage, UPDRS scores, or olfactory sulcus depths, likely reflecting loss that precedes motor system and olfactory sulcus damage PD < DIP;DIP = HCs B-SIT scores higher in DIP than in PD and 14 of 15 were within normal range The one outlier exhibited marked decreased cardiac MIBG uptake similar to that of PD The parkinsonism in this case was more persistent on withdrawal of the offending drug 80% of PD cases had a smell deficit Lower scores noted in those initially presenting with resting tremor, rigidity, and bradykinesia

control

transporter PET

Ferreira et al 729

UPSIT R

2007 3

Cross

11LRRK2

sectional

mutation carrying PD identified from144 unrelated PD probands

Kimet al 730

2007 4

Case

59PD 25HCs

B-SIT

control

Lee et al 731

B-SIT

2007b 4

Case

24PD 15DIP 15HCs

control

Quagliato et al 732

2007 4

Case

50PD 76HCs

B-SIT

control

(Continues)