xRead - Olfactory Disorders (September 2023)

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493

PATEL et al.

TABLE VIII.3 (Continued) Study

Year LOE Study design

Study groups 40 patients with isolated congenital anosmia 22 normosmic controls

Clinical end point OF (detection and recognition) OB, OS olfactory groove, and

Conclusions

Patients with congenital anosmia may show aplastic or hypoplastic OB, decreased OS depths, and/or abnormalities in hippocampal anatomy MRI and SPECT had high sensitivity and specificity in the diagnosis of posttraumatic anosmia, with SPECT having better performances than MRI OBV correlated with OF at baseline and with the improvement of OF at follow-up retronasal) olfactory tests OF correlated with OBV Retronasal function was more affected with more extensive cerebral lesions Parosmia was associated with smaller OBs and correlated to OF, was decreased with duration of olfactory loss, and was smaller in patients with parosmia abnormalities of the OB, olfactory tract, OS, or gyrus rectus Posttraumatic lesions were mainly seen in OB, olfactory tract, subfrontal and temporal lobes OB volume correlated with identification performances; PT patients had smaller OBVs 7 patients had OBV correlated to psychophysical (orthonasal and the presence of cerebral damage OBV was negatively

Levy

2013 4

Retrospective cohort

et al 1069

hippocampal morphology

Atighechi et al 1070

2013 4

Retrospective case series

63 patients with PTOD

CCCRC olfactory test MRI: abnormalities of the OB, olfactory tract, and frontal and temporal lobes SPECT: perfusion in

the frontal and temporal lobes

Rombaux et al 1071

SS-TDI (baseline and follow-up) MRI:OBV Recovery SS-TDI and powder retronasal odor identification) Chemosensory ERPs OBV SS-TDI and powder retronasal odor identification OBV and brain damages

2012 4

Prospective case series

60 patients with OD(28 postinfectious, 32 posttraumatic) 122 patients with PIOD

Rombaux et al 241

2009 4

Retrospective case series

Rombaux et al 1072

2006 4

Retrospective case series

25 patients with PTOD

Rombaux et al 1031

2006 4

Retrospective case series

26 patients with PIOD

SS-TDI OBV

Aiba

Olfactory pathway morphology

2004 4

Prospective case series

9 patients with congenital anosmia 36 patients with PTOD 24 normosmic controls

et al 934

Yousem

1999 4

Prospective case series

UPSIT R OB, olfactory tract, temporal lobes

et al 310

(Continues)