xRead - Olfactory Disorders (September 2023)

20426984, 2022, 4, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/alr.22929, Wiley Online Library on [04/09/2023]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License

548

INTERNATIONAL CONSENSUS ON OLFACTION

TABLE IX.2 Section evidence summary: Management of PTOD Study Year LOE Design Study groups

Clinical end point SS-TDI outcomes: 10% improved, 83% no change 7% worsened SS-TDI outcomes: 33% of patients with OT and 13% of controls improved T&T olfactometer outcomes: 41.7% improved by TSS 28.8% improved by Kamikihito T&T olfactometer outcomes: 2 of 6 (33%) improved by TSS and 6 of 7 (86%) by Kamikihito PEA threshold outcomes: 11 of 39 (28%) improved by zinc gluconate and prednisolone 9 of 35 (26%) zinc gluconate only 4 of 34 (12%) prednisolone only 1 of 37 (3%) no medication T&T olfactometer outcomes: 2 of 4 (50%) improved with zinc sulfate 11 of 70 (43%) by steroids and systemic vitamin Bcomplex 9 of 21 (16%) by zinc sulfate and the complex measured by patients’ self-reported scores

Conclusions Spontaneous

Reden

2006 4

Retrospective 99 patients with PTOD Observation

improvement rate of posttraumatic olfactory loss was poor

Konstantinidis 2013 3

Prospective

38 patients with PTOD 23 of 38 patients with OT for 16 weeks 15 ot 38 control patients

OT is useful for

treatment of PTOD

No significant difference in improvement rates between TSS and topical steroids Kamikihito is useful for treatment of posttraumatic dysfunction

Miwa

2005 4

Retrospective PTOD TSS vs topical steroids

Shiga

2014 4

Retrospective 13 patients with PTOD 6of 13TSS 7 of 13 Kamikihito

Zinc gluconate has a promising effect in

Jiang

2015 2

Prospective

145 patients with PTOD 39 of 145 zinc gluconate for month and prednisolone for 2 weeks 35 of 145 zinc gluconate only 34 of 145 prednisolone only 37 of 145 no medication

treating posttraumatic anosmia

Aiba

1998 4

Retrospective 95 patients with PTOD 4 of 95 zinc sulfate 300 mg/day 70 of 95 topical

Zinc sulfate is

significantly more effective than steroids and systemic vitamin B complex against PTOD

corticosteroids and systemic vitamin B complex 21 of 95 zinc sulfate and the complex

Positive responders on olfactory tests at the first visit get better recovery of OF than nonresponders Patients with PTOD treated with topical steroids had poor recovery and prognosis

Kitano

2013 4

Retrospective 57 patients with PTOD T&T olfactometer and intravenous olfactory test (Alinamin test) results: 45% improvement rate

Mori

1998 4

Retrospective 108 patients with PTOD Topical corticosteroids

T&T olfactometer and intravenous olfactory test (Alinamin test) results: 25% of improvement rate by patients’ self-reported scores

(Continues)