xRead - Olfactory Disorders (September 2023)

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574

INTERNATIONAL CONSENSUS ON OLFACTION

TABLE IX-18 Evidence for CRS-related olfactory loss management with ESS Study Year LOE Study design Study groups

Clinical end point Conclusions

SS-TDI UPSIT R VAS QOD-NS B-SIT

Zhao

ESS appears to be beneficial for

2020 2

Meta-analysis

35 studies including 3164 patients with

et al 1446

improvement of OF in patients with CRSwNP Benefit is less clear in CRSsNP Further thorough and comprehensive studies need to be conducted

CRS were eligible for the meta-analysis

Moreno-luna R et al 1448

2019 3

Prospective cohort

CRSwNP ESS with mucoplasty (free mucosal graft to ethmoid) (n = 10) CRSwNP (N = 40) Eosinophilic polyps (n = 21) Noneosinophilic polyps (n = 19)

VAS

No significant

improvement in olfaction

Zhang

SS-TDI

Significant

2019 4

Retrospective

et al 1449

improvement in SS wasnoted improved by MCID (5.5) Improvement in VAS wasnoted 50% of patients improvement in QOD-NS noted MCIDof 5.2 Majority of patients reporting abnormal baseline QOD-NS achieved an MCID Significant

Li

2018 4

Retrospective study CRSwNP (n = 26)

VAS

et al 1450

Mattos

2018 3

Observational,

CRS (n = 128)

QOD-NS

et al 1246

multicenter cohort

Walliczek

2018 3

Prospective cohort

CRSwNP (n = 21

SS-TDI STS

Significant

Dworschak et al 1451

improvement in SS but not STS

Haxel

2017 3

Prospective cohort

CRS (n = 41)

SS-ID (16 odors)

Significant

et al 1452

improvement in SS

Kohli

2016 2

Meta-analysis

Mixed CRS patients

VAS SNOT-22 UPSIT R SS-TDI B-SIT

ESS improves nearly all subjective and objective measures of olfaction in patients with CRS patients

et al 1447

Patients with nasal polyposis or preoperative OD

improve to a greater degree

Andrews et al 1453

2016 3

Prospective cohort

CRSwNP (n = 60) CRSsNP (n = 53)

UPSIT R VAS

Significant

improvement in UPSIT R andVAS

Chen

2016 3

Prospective, single institute cohort Prospective cohort

CRSwNP (n = 42)

VAS

Significant

et al 1454

improvement in VAS

Lind

2016 3

CRSwNP (n = 75) CRSsNP (n = 22)

SS-ID (12 odors)

Significant

et al 1455

improvement in SS

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