xRead - Olfactory Disorders (September 2023)

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381

PATEL et al.

TABLE VII.8 Section evidence summary: Related to RT Study

Year LOE Study design Study groups

Clinical end point

Conclusions

2017 2 *

Álvarez

Systematic review 23 studies

OD as a side effect of RT Odor detection,

Camacho et al 388

N = 13 to 1411 patients

identification, and discrimination are impaired after RT for HNC exists between RT and odor identification and discrimination patients with HNC treated with high doses to the OE had worsened odor thresholds and identification scores Significant differences in the latency and amplitude of olfactory ERPs between patients and controls, correlating with subjective olfactory assessments Decrease in objective OF during RT with improvement after 3 months, but persistent During RT, there was no significant difference in odor threshold or identification between groups, but discrimination was significantly lower in those receiving a higher dose of RT Odor identification was lower in patients with higher dose to the OE ≥ 6 months post-RT A dose relationship 20 months after RT, than those treated with low-dose RT mucociliary dysfunction

Brämerson et al 385

2013 3

Cohort

14 patients with HNC whose treatment included high-dose RT to the OE 56 patients with HNC whose treatment included RT sparing the OE

SOIT

Galletti

Olfactory ERPs Hyposmia Rating Scale Olfactory VAS

2016 4

Case-control

9 patients with NPC treated withRTand chemotherapy 9HCs

et al 389

Gurushekar et al 382

2020 3

Cohort

13 patients with HNC undergoing RT

CCCRC olfactory test Mucociliary clearance AHSP questionnaire

Hölscher et al 384

SS-ID, SS-D, SS-T

2005 3

Cohort

22 patients undergoing head and neck RT with a high dose to the OE 22 patients undergoing H&N RT with a low dose to the OE

Jalali

2014 3

Cohort study

54 patients with HNC or brain malignancy

n-Butanol threshold In vivo dosimetry

Reduced olfactory thresholds scores

et al 393

(elevated thresholds) 6 months after RT, witha dose-dependent response

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