xRead - Recurrent Respiratory Papillomatosis (October 2025)

M. Filauro et al.

Table II. Characteristics of the entire cohort. Variable

Overall (n = 48)

Treatment protocol

p value

New (n = 35)

Historical (n = 13)

Age (years) Median (IQR)

0.18

45 (26.7)

46 (27.5)

40 (21) 14-78

Range

14-83

19-83

Gender Female

> 0.99

17 (35%) 31 (65%)

12 (34%) 23 (66%)

5 (38%) 8 (62%)

Male

Smoking

> 0.99

No

33 (82%) 7 (18%)

27 (82%) 6 (18%)

6 (86%) 1 (14%)

Yes

No. of previous treatments

0.15

Median (IQR)

2 (2) 0-29

2 (3.5)

1 (2)

Range

0-29

0-7

FU time (months)

0.52

Median (IQR)

29 (30.2)

26 (22.5)

36 (54)

Range

1-83

5-77

1-83

No. of treatments

0.42

Median (IQR)

4 (4) 1-17

4 (4) 1-17

4 (3) 2-15

Range

No. office-based treatments

< 0.001

Median (IQR)

3 (5.2)

3 (3.5)

0 (0)

Range

0-17

0-17

0-0

No. general anaesthesia treatments

< 0.001

Median (IQR)

1 (2.2)

1 (1)

4 (3) 2-15

Range

0-15

0-4

No. of no-treatments

< 0.001

Median (IQR)

0 (2)

1 (2)

0 (0)

Range

0-7

0-7

0-0

Time interval between procedures (months)

0.26

Median (IQR)

3.45 (6.1)

3.22 (3.9)

8.4 (9)

Range

1-64 1-64 IQR: interquartile range. FU: follow-up. Differences between the two treatment groups were analysed with the Mann Whitney U and χ 2 or Fisher’s exact test when appropriate. 1-14.2

100 = maximal discomfort) was used to assess the overall unpleasantness of the intervention.

TOLMS included preoperative outpatient clinic assess ment, supplies, OR and GA costs, recovery room, one-night hospitalisation (as for our hospital protocol), and staff fees. For OB procedures, the costs of outpatient clinic examina tion, local anesthetic drugs, fiber laser supply, instrument sterilisation, and staff fees were considered.

Cost assessment A cost assessment was drawn up by comparing TOLMS and OB costs for a single RRP procedure. The costs of the

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