xRead - Recurrent Respiratory Papillomatosis (October 2025)

In-office vs operating room treatments for RRP

and contribute to paper revision; CS, AI: analysed the data and contributed to paper revision. PB, GG, MDV collected the data; GP: contributed to paper revision. All the authors read and approved the final version of the manuscript. Ethical consideration This study was approved by the Institutional Ethics Com mittee (Comitato Etico Regionale della Liguria, protocol number 63/2021). The research was conducted ethically, with all study pro cedures being performed in accordance with the require ments of the World Medical Association’s Declaration of Helsinki. Written informed consent was obtained from each patient for study participation and data publication. 1 Derkay CS, Wiatrak B. Recurrent respiratory papillomatosis: a re view. Laryngoscope 2008;118:1236-1247. https://doi.org/10.1097/ MLG.0b013e31816a7135 2 Taliercio S, Cespedes M, Born H, et al. Adult-onset recurrent res piratory papillomatosis: a review of disease pathogenesis and impli cations for patient counseling. JAMA Otolaryngol Head Neck Surg 2015;141:78-83. https://doi.org/10.1001/jamaoto.2014.2826 3 Bertino G, Pedretti F, Mauramati S, et al. Recurrent laryngeal papillo matosis: multimodal therapeutic strategies. Literature review and mul ticentre retrospective study. Acta Otorhinolaryngol Ital 2023;43:111 122. https://doi.org/10.14639/0392-100X-suppl.1-43-2023-14 4 Silverberg MJ, Thorsen P, Lindeberg H, et al. Clinical course of re current respiratory papillomatosis in Danish children. Arch Otolar yngol Head Neck Surg 2004;130:711-716. https://doi.org/10.1001/ archotol.130.6.711 5 Shah MD, Johns MM 3 rd . Office-based laryngeal procedures. Oto laryngol Clin North Am 2013;46:75-84. https://doi.org/10.1016/j. otc.2012.08.019 6 Remacle M, Arens C, Eldin MB, et al. Laser-assisted surgery of the upper aero-digestive tract: a clarification of nomenclature. A con sensus statement of the European Laryngological Society. Eur Arch Otorhinolaryngol 2017;274:3723-3727. https://doi.org/10.1007/ s00405-017-4708-3 7 Derkay CS, Malis DJ, Zalzal G, et al. A staging system for assess ing severity of disease and response to therapy in recurrent respira tory papillomatosis. Laryngoscope 1998;108:935-937. https://doi. org/10.1097/00005537-199806000-00026 8 Filauro M, Mora F, Vallin A, et al. Evone ® Flow controlled ventilation: a new device for laryngotracheal surgery. Acta Otorhinolaryngol Ital 2022;42:189-193. https://doi.org/10.14639/0392-100X-N1834 9 Filauro M, Vallin A, Fragale M, et al. Office-based procedures in lar yngology. Acta Otorhinolaryngol Ital 2021;41:243-247. https://doi. org/10.14639/0392-100X-N0935 References

10 Jacobson BH, Johnson A, Grywalski C, et al. The Voice Handicap Index (VHI): development and validation. Am J Speech Lang Pathol 1997;6:66-69. https://doi.org/10.1044/1058-0360.0603.66 11 Clavien PA, Barkun J, de Oliveira ML, et al. The Clavien-Dindo clas sification of surgical complications: five-year experience. Ann Surg 2009;250:187-196. https://doi.org/10.1097/SLA.0b013e3181b13ca2 12 Armstrong LR, Derkay CS, Reeves WC. Initial results from the na tional registry for juvenile-onset recurrent respiratory papillomatosis. RRP Task Force. Arch Otolaryngol Head Neck Surg 1999;125:743 748. https://doi.org/10.1001/archotol.125.7.743 13 Bishai D, Kashima H, Shah K. The cost of juvenile-onset recur rent respiratory papillomatosis. Arch Otolaryngol Head Neck Surg 2000;126:935-939. https://doi.org/10.1001/archotol.126.8.935 14 Motz KM, Hillel AT. Office-based management of recurrent respira tory papilloma. Curr Otorhinolaryngol Rep 2016;4:90-98. https://doi. org/10.1007/s40136-016-0118-0 15 Zeitels SM, Franco RAJ, Dailey SH, et al. Office-based treatment of glottal dysplasia and papillomatosis with the 585-nm pulsed dye laser and local anesthesia. Ann Otol Rhinol Laryngol 2004;113:265-276. https://doi.org/10.1177/000348940411300403 16 Rees CJ, Halum SL, Wijewickrama RC, et al. Patient tolerance of in-office pulsed dye laser treatments to the upper aerodigestive tract. Otolaryngol Head Neck Surg 2006;134:1023-1027. https://doi. org/10.1016/j.otohns.2006.01.019 17 Zeitels SM, Akst LM, Burns JA, et al. Office-based 532-nm pulsed KTP laser treatment of glottal papillomatosis and dyspla sia. Ann Otol Rhinol Laryngol 2006;115:679-685. https://doi. org/10.1177/000348940611500905 18 Hess MM, Fleischer S, Ernstberger M. New 445 nm blue laser for la ryngeal surgery combines photoangiolytic and cutting properties. Eur Arch Otorhinolaryngol 2018;275:1557-1567. https://doi.org/10.1007/ s00405-018-4974-8 19 Filauro M, Ioppi A, Vallin A, et al. Office-based treatment of vocal fold polyps and Reinke’s edema: a rational comparison with suspen sion laryngoscopy. Laryngoscope 2023;133:2665-2672. https://doi. org/10.1002/lary.30576 20 Miller BJ, Abdelhamid A, Karagama Y. Applications of office-based 445 nm blue laser transnasal flexible laser surgery: a case series and review of practice. Ear Nose Throat J 2021;100:105S-112S. https:// doi.org/10.1177/0145561320960544 21 Lin RJ, Iakovlev V, Streutker C, et al. Blue light laser results in less vocal fold scarring compared to KTP laser in normal rat vocal folds. Laryngoscope 2021;131:853-858. https://doi.org/10.1002/lary.28892 22 Cole RR, Myer CM 3 rd , Cotton RT. Tracheotomy in children with recurrent respiratory papillomatosis. Head Neck 1989;11:226-230. https://doi.org/10.1002/hed.2880110306 23 Parker LA, Kunduk M, Blouin D, et al. Voice outcomes following multiple surgeries for recurrent respiratory papillomatosis. J Voice 2020;34:791-798. https://doi.org/10.1016/j.jvoice.2019.02.004 24 Schimberg AS, Wellenstein DJ, van den Broek EM, et al. Office-based vs. operating room-performed laryngopharyngeal surgery: a review of cost differences. Eur Arch Otorhinolaryngol 2019;276:2963-2973. https://doi.org/10.1007/s00405-019-05617-z 25 Woisard V, Alexis M, Crestani S, et al. Safety of office-based flex ible endoscopic procedures of the pharynx and larynx under topical anesthesia. Eur Arch Otorhinolaryngol 2022;279:5939-5943. https:// doi.org/10.1007/s00405-022-07525-1

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