2018 Section 5 - Rhinology and Allergic Disorders

DURHAM AND PENAGOS

J ALLERGY CLIN IMMUNOL VOLUME 137, NUMBER 2

TABLE E3. Local and systemic reactions and adrenaline use reported in RCTs included in a Cochrane SR on subcutaneous immunotherapy for AR 9

SCIT

Placebo

Type of reaction

RCTs

No.

Total events (% participants)

No.

Total events (% participants)

Local

Not requiring treatment Requiring treatment

24

907 208

834 (92) 21 (10)

697 186

227 (33)

7

8 (4)

Systemic Early systemic reaction, grade 2 (<30 min) Early systemic reaction, grade 3 (<30 min) Early systemic reaction, grade 4 (<30 min)

17 13

706 615 417 514

154 (22)

566 463 303 412

44 (8)

43 (7)

3 (0.65) 1 (0.33)

9

3 (0.72)

Late systemic reaction (>30 min)

11 13

458 (89)

148 (36)

Adrenaline use

557 19 (3.41); injections, 14,085 (0.13%)

404 1 (0.25); injections, 8,278 (0.01%)

172