2018 Section 5 - Rhinology and Allergic Disorders

DURHAM AND PENAGOS

J ALLERGY CLIN IMMUNOL February 2016

TABLE E4. Local and systemic reactions and adrenaline use reported in RCTs included in a Cochrane SR on SLIT for AR 36,37

SLIT

Placebo

Type of reaction

RCTs

No.

Total events (per participant)

No.

Total events (per participant)

Local

Labial edema Buccal pruritus

11 21

604

55 (0.09)

536

7 (0.01)

1126

1798 (1.6)

1075

492 (0.46)

Buccolingual edema Throat irritation Oral (nonspecified) Local nonspecified

8

648 770

143 (0.22) 243 (0.3) 143 (2.1)

606 747

2 (0.003)

10

29 (0.04) 24 (0.34) 3 (0.03)

3 3

68

71

119

7 (0.06)

116

Systemic

Urticaria

8

204 363 262 965 184 488 337 630 535 291 330

7 (0.03) 13 (0.04) 774 (2.95) 1403 (1.45) 60 (0.33) 51 (0.1) 313 (0.93) 88 (0.14)

199 222 238 912 176 450 304 561 548 288

9 (0.04) 9 (0.04)

Pruritis/rash Conjunctivitis

10

8

786 (3.3)

Rhinitis

16

1034 (1.13) 58 (0.33) 42 (0.09) 211 (0.69) 10 (0.02) 68 (0.12)

Rhinoconjunctivitis

6

Asthma/wheeze

15

Cough

8

Gastrointestinal

20

Headache

6 6 5 0

70 (0.2)

Anaphylaxis

0

0 0 0

Systemic nonspecified

4 (0.01)

36

Adrenaline use

0

0

0

Reprinted with permission from Radulovic et al. 37

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