2018 Section 5 - Rhinology and Allergic Disorders

DURHAM AND PENAGOS

J ALLERGY CLIN IMMUNOL VOLUME 137, NUMBER 2

Placebo

(Continued)

Sensitization status

presentation, taste

(SLIT), and color to the active therapy

(drops) and

histamine

dihydrochloride (injection)

histamine

dihydrochloride

plus aluminum hydroxide

(injection)

ugar (drops)

and histamine

dihydrochloride (injection)

1. HDM sensitization: 11% to 14% 2. Grass pollen

symptoms June-

July: 38% to 56%

1. Patients sensitized to other inhalant allergens were excluded.

1. Participants in this study were monosensitized to cypress.

1. Participants included in this trial were monosensitized to HDM.

First author, year, country Units Frequency Dose Duration Frequency Dose Duration Cumulative dose Frequency Dose Duration Frequency Dose Duration Cumulative dose Khinchi et al, 47 2004, Denmark Every second day Initial: 0.0164 m g Top: 49.2 m g of Bet v 1 30 days Every second day 49.2 m g of Bet v 1 21-23 months 11.18 mg of Bet v 1 m g SLIT: Swallow Drops Weekly Initial: 0.0164 m g Top: 3.28 m g of Bet v 1 12 weeks Monthly 3.28 m g of Bet v 1 21 months 51 m g of Bet v 1 m g Caramelized s BU a week ; 6.25 BU Spit ; 20 BU Units SLIT method

8 months 210 BU BU Identical appearance,

Swallow Drops Weekly NA 12 weeks Monthly NA 9 months NA IR Sugar (drops) and

TU Caramelized sugar

8 months 43,770 TU ( D pteronyssinus 21,885 of TU and D farinae 21,885 TU)

group (no.) Age (y) Inclusion criteria Asthma SLIT: 39%

SCIT: 29%

Placebo: 37%

SLIT: 80%

SCIT: 80%

SLIT: NA

SCIT: NA

SLIT: 100%

SCIT: 100%

2. Positive sIgE level and SPT response for both D pteronyssinus and D farinae

Build-up phase Maintenance phase

or MTD

or MTD

4,000 TU

blind, double-dummy, placebo controlled study Birch (Bet v 1) 3 23 24 24 30 (20-58) 1. 2 y of birch-associated ARC

2. Positive sIgE level, conjunctival provocation test

result, and SPT

response to birch pollen

Double-blind, double- dummy controlled study Grass mix 2 10 10 — 27 (13-39) 1. Clinical history of grass pollen sensitization

2. Positive sIgE level and SPT response to grass pollen

Randomized, double- blind, placebo- controlled study Juniperus ashei 4 10 10 SL: 10 SC: 10 39 6 2.4 (18-55) 1. ARC correlated with the cypress pollen season.

2. Positive sIgE level and SPT response to grass pollen

1. Clinical history of at least 1 year of rhinitis

with asthma associated with HDM.

SLIT SCIT

3 weeks

4 weeks

Placebo: 10.1 6 2.7

D pteronyssinus and D farinae 3 11 10 10 SLIT: 9.2 6 3.4 SCIT: 10.9 6 3.2

12 weeks Every

12 weeks Every

; 20 BU

0.025 BU Top:

10 TU

4,000 TU

Top:

Placebo

Weekly Initial:

Weekly Initial:

Drops

Swallow Drops

SCIT

11 months 510 BU BU SLIT:

IR SLIT:

TU SLIT:

group (no.)

1400 TU 8 months 173,733 TU ( D pteronyssinus 86,867 TU and D farinae 86,867 TU)

SLIT

11 months ; 30 mg of Jun a 1

group (no.)

No. of

groups

Build-up phase Maintenance phase

228 m g of

or MTD

Jun a 1

TABLE E5. Head-to-head double-blind, controlled trials of SLIT versus SCIT for allergic rhinitis First author, year, country Study design Allergen Khinchi et al, 47 2004, Denmark Randomized, double- Quirino et al, 48 1996, Italy Ventura et al, 49 2009, Italy Yukselen et al, 38 2012, Turkey Randomized, double- blind, double-dummy, placebo-controlled study

a week

a week

; 25 days 3 times

Ventura et al, 49 2009, Italy NA NA 30 days 3 times

12 weeks 3 times

Top: ; 6.25

BU

0.5 TU Top:

1400 TU

Daily Initial: 0.002

Daily Initial:

Yukselen et al, 38

Quirino et al, 48 1996, Italy

2012, Turkey

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