2018 Section 5 - Rhinology and Allergic Disorders

Levy et al

Table 3. Commercial Conflicts of Interests in Included Studies.

Industry Sponsor a

Study Support b

Financial Relationships c

Source

Study

Abreu 19 2014 Achar 20 2012

No

No

No

N/A

Unknown

Unknown

Unknown

Not reported Acclarent Inc

Albritton 11 2012 Bikhazi 21 2014 Bolger 22 2007 Brodner 23 2013 Cutler 24 2013 Friedman 25 2008

Yes Yes Yes Yes Yes No Yes Yes No Yes

Yes No Yes No No No No Yes No No

Yes Yes Yes Yes Yes No Yes Yes Yes Yes

Entellus Medical Inc

Acclarent Inc

Entellus Medical Inc Entellus Medical Inc

N/A

Gould 26 2014

Entellus Medical Inc

Karanfilov 27 2013 Koskinen 28 2012

Acclarent Inc

N/A

Kuhn 29 2008

Acclarent Inc Not reported Acclarent Inc

Kutluhan 30 2009 Levine 31 2008

Unknown

Unknown

Unknown

Yes No

No No

Yes No

Luong 13 2008

N/A

Raghunandhan 32 2013

Unknown

Unknown

Unknown

Not reported Acclarent Inc

Weiss 33 2008

Yes

Yes

Yes

Abbreviation: N/A, not applicable. a Commercial funding in support of study. b Administrative and logistical support. c Author financial relationships including consulting fees and stock options related to balloon catheter dilation.

Figure 2. Change in 20-Item Sinonasal Outcome Test score following balloon catheter dilation.

Figure 3. Change in 20-Item Sinonasal Outcome Test score 6 months following balloon catheter dilation.

threshold of 0.8 in absolute value and may therefore be consid- ered clinically significant. 34 Additionally, the magnitude and duration of improvement in quality of life extend beyond the confounding response shift described following ESS. 35 Several groups of studies—including CLEAR, 22,29,33 ORIOS, 11,27 and REMODEL 21,24 —report outcomes at increasing duration of follow-up for a single group of patients after BCD. While data

were not present to directly evaluate change in outcome para- meters for individual patients at multiple durations of follow- up, it was possible to include each time point as a separate out- come measure for quantitative analysis. Subgroup analysis of patients undergoing BCD in the office setting maintained a clinically significant reduction in the weighted mean SNOT-20 score, although significantly

219