2018-19 Section 7-Neoplastic and Inflammatory Diseases of the Head and Neck eBook

Age, mean 6 SD 59.0 6 13.0 61.0 6 12.6 1.012 (0.998-1.026) .09 OR time, mean 6 SD, min 518.6 6 128.3 566.7 6 127.9 1.003 (1.002-1.004) \ .01 1.003 (1.002-1.005) \ .01 EBL, median (range), cc 320 (25-2400) 400 (50-4750) 1.0006 (1.00005-1.00112) .03 Crystalloid given intraoperatively, mean 6 SD 5234.9 6 1664.6 5742.4 6 2161.6 1.0001 (1.00005-1.00023) \ .01 CCI, mean 6 SD 4.6 6 2.1 5.3 6 2.4 1.15 (1.06-1.25) \ .01 1.21 (1.11-1.32) \ .01 Male sex 154 (65.0) 187 (67.3) 1.11 (0.77-1.60) .58 Recurrent tumor 76 (32.1) 94 (33.8) 1.08 (0.75-1.56) .68 Tumor T classification Other 73 (30.8) 57 (20.5) Reference Mucosal SCC, T1-T2 55 (23.2) 55 (50.0) 1.28 (0.77-2.13) .34 Mucosal SCC, T3-T4 109 (46.0) 166 (60.4) 1.95 (1.28-2.98) \ .01 Tumor N classification N0 150 (63.3) 150 (54.0) Reference N1-N2a 50 (21.1) 57 (20.5) 1.14 (0.73-1.78) .56 N2b-N3 37 (15.6) 71 (25.5) 1.92 (1.22-3.03) \ .01 Tumor site Other 49 (20.7) 27 (9.7) Reference \ .01

Multivariable P Value

Multivariable

Oral cavity and maxilla 152 (64.1) 186 (66.9) 2.22 (1.33-3.72) \ .01 3.12 (1.76-5.52)

Hypo/larynx/oropharynx 36 (15.2) 65 (23.4) 3.28 (1.76-6.10) \ .01 4.54 (2.31-8.91) Type of free flap Soft tissue 171 (72.1) 174 (62.5) 0.65 (0.44-0.94) .02 Bone containing 66 (27.9) 104 (37.5) Reference Blood transfused 61 (25.7) 99 (36.0) 1.60 (1.10-2.35) .02 Alcoholism 157 (66.2) 164 (59.0) 0.73 (0.51-1.05) .09

Odds Ratio (95% CI)

Preoperative RT/CCRT 60 (25.3) 85 (30.6) 1.30 (0.88-1.92) .18 Preoperative OPAC 210 (95.0) 245 (92.8) 0.68 (0.31-1.45) .31 Smoking history Never 63 (26.6) 50 (18.0) Reference Yes, current 92 (38.8) 108 (38.8) 1.48 (0.93-2.35) .09 History of heart disease 48 (20.3) 74 (26.6) 1.43 (0.95-2.16) .09 History of pulmonary disease 102 (43.0) 157 (56.5) 1.72 (1.21-2.44) \ .01 History of hypothyroidism 23 (9.7) 46 (16.5) 1.84 (1.08-3.14) .02 History of malnutrition 39 (16.5) 64 (23.0) 1.52 (0.98-2.37) .06 Abbreviations: CCI, Charlson comorbidity index; EBL, estimated blood loss; OPAC, preoperative assessment clinic; OR, operating room; RT/CCRT, radiotherapy/concurrent chemoradiotherapy; SCC, squamous cell carcinoma. a Categorical variables presented as number (%) and continuous variables as mean 6 SD unless otherwise indicated. All variables with P \ .10 in the univariable analysis were considered in the multivariable anal- ysis algorithm, but only the final model is presented. History of hypertension, vasculopathy, renal dysfunction, hepatic disease, and obesity were also tested but are not included in this table as they were not sta- tistically significant between groups. Bold values demonstrate statistical significant in the final multivariable model. Yes, quit in past 82 (34.6) 120 (43.2) 1.84 (1.16-2.94) .01 History of diabetes 30 (12.7) 54 (19.4) 1.66 (1.03-2.70) .04

Univariable P Value

Univariable Odds Ratio (95% CI)

Table 4. Univariable and Multivariable Predictors of Any Complication (54%). a Predictor No Complications (n = 237) Complications (n = 278)

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