2018-19 Section 7-Neoplastic and Inflammatory Diseases of the Head and Neck eBook

Table 5. Univariable and Multivariable Predictors of Wound-Healing Complications (15%). a Predictor No Wound-Healing Complication (n = 438) Wound-Healing Complication (n = 77) Crystalloid given intraoperatively, mean 6 SD 5333.7 6 1816.3 6500.0 6 2430.8 1.0003 (1.0002-1.0004) \ .01 1.21 (1.05-1.38) \ .01 CCI, mean 6 SD 5.0 6 2.4 4.7 6 1.9 1.05 (0.94-1.18) .36 Male sex 294 (67.1) 47 (61.0) 0.77 (0.47-1.26) .30 Recurrent tumor 144 (32.9) 26 (33.8) 1.04 (0.63-1.73) .88 Tumor T classification Other 122 (27.9) 8 (10.4) Reference Mucosal SCC, T1-T2 92 (21.0) 18 (23.4) 2.97 (1.23-7.19) .01 Mucosal SCC, T3-T4 224 (51.1) 51 (66.2) 3.46 (1.58-7.57) \ .01 Tumor N classification N0 259 (59.1) 41 (53.2) Reference N1-N2a 89 (20.3) 18 (23.4) 1.28 (0.70-2.36) .43 N2b-N3 90 (20.6) 18 (23.4) 1.27 (0.69-2.33) .45 Tumor site .01 Other 75 (17.1) 1 (1.3) Reference Univariable Odds Ratio (95% CI) Univariable P Value Multivariable Odds Ratio (95% CI) Multivariable P Value Age, mean 6 SD, y 60.3 6 13.1 58.7 6 11.0 0.99 (0.97-1.01) .29 OR time, mean 6 SD, min 533.4 6 127.3 607.4 6 129.3 1.004 (1.002-1.006) \ .01 1.24 (1.09-1.41) \ .01 EBL, median (range), cc 350 (25-4750) 400 (50-2300) 0.99996 (0.9993-1.0005) .89

Oral cavity and maxilla 283 (64.6) 55 (71.4) 14.6 (2.0-107.7) \ .01 19.1 (2.5-144.0) Hypo/larynx/oropharynx 80 (18.3) 21 (27.3) 19.7 (2.6-151.2) \ .01 24.2 (3.1-190.5) Type of free flap Soft tissue 306 (69.9) 39 (50.6) 0.44 (0.27-0.72) \ .01 Bone containing 132 (30.1) 38 (49.4) Reference Blood transfused 133 (30.6) 27 (35.1) 1.23 (0.74-2.06) .42 Alcoholism 276 (63.0) 45 (58.4) 0.83 (0.51-1.35) .45 Preoperative RT/CCRT 117 (26.7) 28 (36.4) 1.57 (0.94-2.61) .08 Preoperative OPAC 389 (93.7) 66 (94.3) 1.11 (0.38-3.25) .86 Smoking history Never 100 (22.8) 13 (16.9) Reference Yes, current 173 (39.5) 27 (35.1) 1.20 (0.59-2.42) .61 History of pulmonary disease 215 (49.1) 44 (57.1) 1.38 (0.84-2.25) .19 History of hypothyroidism 57 (13.0) 12 (15.6) 1.23 (0.62-2.45) .54 History of malnutrition 82 (18.7) 21 (27.3) 1.63 (0.94-2.83) .09 Abbreviations: CCI, Charlson comorbidity index; EBL, estimated blood loss; OPAC, preoperative assessment clinic; OR, operating room; RT/CCRT, radiotherapy/concurrent chemoradiotherapy; SCC, squamous cell carcinoma. a Categorical variables presented as number (%) and continuous variables as mean 6 SD unless otherwise indicated. All variables with P \ .10 in the univariable analysis were considered in the multivariable anal- ysis algorithm, but only the final model is presented. History of hypertension, vasculopathy, renal dysfunction, hepatic disease, and obesity were also tested but are not included in this table as they were not sta- tistically significant between groups. Bold values demonstrate statistical significant in the final multivariable model. Yes, quit in past 165 (37.7) 37 (48.1) 1.73 (0.87-3.44) .12 History of diabetes 72 (16.4) 12 (15.6) 0.94 (0.48-1.83) .85 History of heart disease 107 (24.4) 15 (19.5) 0.75 (0.41-1.37) .35

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