2018-19 Section 7-Neoplastic and Inflammatory Diseases of the Head and Neck eBook

Oral cavity and maxilla 297 (65.3) 41 (68.3) 2.48 (0.86-7.16) .09 Hypo/larynx/oropharynx 86 (18.9) 15 (25.0) 3.13 (1.003-9.75) .05 Type of free flap Soft tissue 311 (68.4) 34 (56.7) 0.61 (0.35-1.05) .07 Bone containing 144 (31.6) 26 (43.3) Reference Preoperative RT/CCRT 123 (27.0) 22 (36.7) 1.57 (0.89-2.77) .86 Preoperative OPAC 401 (93.3) 54 (98.2) 3.90 (0.53-28.77) .18 Smoking history Never 102 (22.4) 11 (18.3) Reference History of diabetes 68 (14.9) 16 (26.7) 2.08 (1.11-2.89) .02 2.47 (1.28-4.77) \ .01 History of malnutrition 85 (18.7) 18 (30.0) 1.86 (1.01-3.41) .04 1.89 (1.03-3.50) .04 Abbreviations: CCI, Charlson comorbidity index; EBL, estimated blood loss; OPAC, preoperative assessment clinic; OR, operating room; RT/CCRT, radiotherapy/concurrent chemoradiotherapy; SCC, squamous cell carcinoma. a Categorical variables presented as number (%) and continuous variables as mean 6 SD unless otherwise indicated. All variables with P \ .10 in the univariable analysis were considered in the multivariable anal- ysis algorithm, but only the final model is presented. History of hypertension, vasculopathy, renal dysfunction, hepatic disease, and obesity were also tested but are not included in this table as they were not sta- tistically significant between groups. Bold values demonstrate statistical significant in the final multivariable model. History of heart disease 110 (24.2) 12 (20.0) 0.79 (0.40-1.53) .48 History of pulmonary disease 226 (49.7) 33 (55.0) 1.23 (0.71-2.14) .44 History of hypothyroidism 58 (12.7) 11 (18.3) 1.54 (0.76-3.11) .24 Yes, current 176 (38.7) 24 (40.0) 1.26 (0.60-2.65) .54 Yes, quit in past 177 (38.9) 25 (41.7) 1.31 (0.62-2.76) .48 Blood transfused 144 (31.9) 16 (26.7) 0.78 (0.42-1.43) .43 Alcoholism 283 (62.2) 38 (63.3) 1.05 (0.60-1.86) .86

Table 6. Univariable and Multivariable Predictors of Wound Infection Complications (12%). a Predictor No Wound Infection (n = 455) Wound Infection (n = 60) EBL, median (range), cc 350 (25-4750) 400 (50-2300) 0.9999 (0.9991-1.0007) .26 Crystalloid given intraoperatively, mean 6 SD 5449.9 6 1975.8 5951.7 6 1816.5 1.0001 (1.0000-1.0002) .07 CCI, mean 6 SD 5.0 6 2.3 4.8 6 2.1 0.96 (0.84-1.08) .47 Male sex 297 (65.3) 44 (73.3) 1.46 (0.80-2.68) .22 Recurrent tumor 149 (32.7) 21 (35.0) 1.10 (0.63-1.95) .73 Tumor T classification Other 118 (25.9) 12 (20.0) Reference Mucosal SCC, T1-T2 97 (21.3) 13 (21.7) 1.32 (0.58-3.01) .51 Mucosal SCC, T3-T4 240 (52.8) 35 (58.3) 1.43 (0.72-2.85) .31 Tumor N classification N0 265 (58.2) 35 (58.3) Reference N1-N2a 97 (21.3) 10 (16.7) 0.78 (0.37-1.64) .51 N2b-N3 93 (20.4) 15 (25.0) 1.22 (0.64-2.33) .55 Tumor site Other 72 (15.8) 4 (6.7) Reference Univariable Odds Ratio (95% CI) Univariable P Value Age, mean 6 SD, y 60.6 6 13.0 56.3 6 11.4 0.97 (0.95-0.99) .02 0.97 (0.95-0.99) \ .01 OR time, mean 6 SD, min 540.7 6 129.0 573.3 6 136.6 1.002 (1.000-1.004) .07 Multivariable Odds Ratio (95% CI) Multivariable P Value

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