April 2020 HSC Section 4 - Plastic and Reconstructive Problems

Aesth Plast Surg (2015) 39:495–505

Table 3 Specifics of studies of platelet preparations in humans

PRP, L-PRP, or PRFM

Type of study

n

How outcomes were measured

Control Y/N?

Human trials Powell et al. [ 41 ]

PRP

Prospective, randomized, controlled pilot study Prospective, single-blind, pilot study

8 Blinded photo review

Y

Hom et al. [ 42 ]

PRP

80 Biopsy analysis of cellular changes

Y

Danielsen et al. [ 43 ]

PRFM Randomized clinical trial

20 Biopsy analysis of neoepidermal coverage

Y

Danielsen et al. [ 44 ]

PRFM Randomized clinical trial

51 Biopsy analysis and objective measure of wound- breaking strength

Y

Redaelli et al. [ 49 ]

PRP

Case series

23 Photo review, patient and doctor satisfaction score

N

Sclafani [ 50 ]

PRFM Case Series

15 Photo review using Wrinkle Assessment Scale, patient satisfaction score N

Sclafani [ 3 ]

PRFM Retrospective chart review 50 Photo review of clinical results, patient satisfaction score N

Kakudo et al. [ 45 ]

PRP

Split-wound study

1 Biopsy analysis of cellular changes

Y

Na et al. [ 54 ]

PRP

Split-face study

25 Transepidermal water loss, skin color, biopsy analysis Y

Lee et al. [ 52 ]

PRP

Split-face study

14 Chromometer measurements, clinical results using quartile grading scale 68 Single-blind clinical assessment of wound healing, reepithelialization

Y

Chignon-Sicard et al. [ 57 ] PRFM Prospective, randomized, controlled, clinical trial

Y

Sclafani [ 2 ]

PRFM Case series

4 Biopsy analysis of cellular changes

N

Shin et al. [ 55 ]

PRP

Case series

22 Biopsy analysis, patient satisfaction score, clinical assessment

Y

Sclafani [ 58 ]

PRFM Case series

15 Hair density index measurement

N

Schiavone et al. [ 59 ]

L-PRP

Case series

64 Photo review, Jaeschke rating of clinical change

N

Yuksel et al. [ 46 ]

PRP

Case series

10 Patient and doctor clinical grading using 5-point scale N

Mehryan et al. [ 47 ]

PRP

Case series

10 Objective measures using probes, patient satisfaction score, doctor assessment 4-point scale

N

Willemsen et al. [ 48 ]

PRP

Retrospective chart review 82 Photo review by expert panel using questionnaire

N

Gentile et al. [ 51 ]

PRFM Case series

10 Photo review by authors

N

Cervelli et al. [ 60 ]

PRFM Split-scalp study

10 Trichoscan hair measurements, biopsy analysis

Y

Khatu et al. [ 61 ]

PRP

Case Series

11 Photo review, hair pull test, patient satisfaction score N

Gawdat et al. [ 53 ]

PRP

Split-face study

30 Blinded photo review using 4-point scale, patient satisfaction score

Y

Kim and Gallo [ 56 ]

PRFM Prospective split study

15 Blinded photo review using 4-point scale, patient survey Y

et al. applied P-PRP three times at 2-week intervals in ten healthy volunteers. P-PRP was applied to the forehead, malar area, and jaw by a dermaroller, as well as injected using a 27-gage needle into the wrinkles of crow’s feet. They found there was a statistically significant difference between the general appearance, skin firmness–sagging and wrinkle state before and after the applications [ 46 ]. Mehryan et al. assessed the effect of P-PRP on infraorbital dark circles and crow’s feet. Ten participants were treated in a single session with intradermal injections of 1.5 mL P-PRP on each side. The improvement in infraorbital color homogeneity was statistically significant, but no statisti- cally significant changes were observed in melanin content, stratum corneum hydration, wrinkle volume, and visibility

index [ 47 ]. Willemsen et al. found that the addition of P-PRP to grafted autologous fat resulted in a significant drop in the number of days needed to recover before re- turning to work or to restart social activities. The esthetic outcomes were also significantly better than without P-PRP [ 48 ]. Redaelli et al. injected 23 patients with P-PRP in various facial locations and found 30 % reported mild improvement and 61 % reported good improvement [ 49 ]. No control group was used in this study. Sclafani injected autologous PRFM into the dermis and immediate subder- mis below deep nasolabial folds in 15 patients. Over 12 weeks, treated patients had statistically significant re- ductions in wrinkle assessment scores [ 50 ]. Sclafani also reported on 50 patients who were treated with PRFM for

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