April 2020 HSC Section 4 - Plastic and Reconstructive Problems

Aesth Plast Surg (2015) 39:495–505

Table 2 continued

PRP

L-PRP

PRFM

Sclafani [ 3 ]

Improved facial rhytids, scars, volume depletion

Kakudo et al. [ 45 ]

Promoted epithelialization in skin graft donor site Faster recovery, less erythema, thicker collagen after laser Improves appearance of acne scars after laser

Na et al. [ 54 ]

Lee et al. [ 52 ]

Chignon-Sicard et al. [ 57 ]

Faster reepithelialization in hand wound with L-PRF Increased fibroblasts and new collagen deposition

Sclafani [ 2 ]

Shin et al. [ 55 ]

Increased skin elasticity and collagen, decreased erythema after laser

Sclafani [ 58 ]

Increased hair density in androgenetic alopecia

Schiavone et al. [ 59 ]

Improvement in alopecia with enriched plasma proteins

Yuksel et al. [ 46 ]

Improved skin firmness and wrinkles at crow’s feet

Mehryan et al. [ 47 ]

Improved infraorbital color homogeneity

Willemsen et al. [ 48 ]

Improved recovery time and esthetic outcome after fat grafting; enhanced esthetic results with fat transfer or MACS lift with fat

Gentile et al. [ 51 ]

Enhanced maintenance of contour after fat grafting for scar Increased number of hairs and hair density

Cervelli et al. [ 60 ]

Khatu et al. [ 61 ]

Increased hair count in alopecia

Gawdat et al. [ 53 ]

Improved response to treatment of acne scars after laser

Kim and Gallo [ 56 ]

Decreased edema and erythema with ablative fractional CO2 laser

the 6th week. They concluded that this may be useful in the future to increase the success rate of bone grafting [ 39 ]. Reksodiputro et al. in a porcine model demonstrated an increase in collagen type I formation and skin graft taken with the addition of PRFM [ 40 ].

P-PRP-treated wounds closed faster [ 42 ]. Conversely, Danielsen et al. examined the effects of topical autologous PRF on epithelialization of donor sites and meshed split- thickness skin grafts and found no significant difference in epithelialization rates [ 43 ]. A second study found no effect of PRF on incisional wound-breaking strength [ 44 ]. Kakudo et al. compared P-PRP-treated and untreated sides of a split-thickness skin graft donor site, found that ep- ithelialization had progressed more rapidly, pain during gaze change was milder, and at day 13 skin biopsies showed significantly greater epidermal thickness and number of newly formed vessels in the dermis. They concluded that P-PRP promoted epithelialization and an- giogenesis of split-thickness skin graft donor sites [ 45 ]. Several small observational studies have been per- formed looking at effects of P-PRP on facial skin. Yuksel

Human Trials

Twenty-three case series and clinical trials were included in this review. These studies vary in design, size, and power (Table 3 ). Powell et al. sprayed P-PRP beneath deep plane facelift flaps prior to wound closure and found a trend toward decreased edema and ecchymosis over the first 12 days after a facelift in eight treated hemifaces [ 41 ]. Hom et al. looked at the healing effects of P-PRP on thigh skin puncture wounds and found that, compared to control,

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