FLEX November 2023

COSTANTINO ET AL . 2291

TABLE 1

Characteristics of included studies

SLN identification (%)

SLNB positive rate (%)

RRR (%)

Study

N (male) Age (range)

Criteria for high risk

SLNB technique

FU (months)

5 (NA)

NA

Size greater than 2 cm

SPECT/CT + Gamma probe

4/5 (80%)

0/4 (0%)

0/5 (0%) NA

Agrawal et al. 44

20 (17)

Median 66 (range 39 – 72)

Size greater than 2 cm; location on lower lip Size greater than 2 cm; tumor thickness >8 mm or Clark level IV; immunosuppression; tumor site; site of scar; ALI; PNI; tumor budding; poor differentiation; rapid growth Tumor site; tumor size >2 cm; depth of invasion >4 mm; moderately or poor differentiation; perineural invasion; recurrent tumors Breslow depth >2 mm or Clark level of IV or V; rapid growth; recurrent tumor; occurrence in a prior radiation or chronic inflammation and/or ulcer site; PNI; ALI; immunosuppression; size of 1 cm or more on the cheek, forehead, scalp, neck, or 0.6 cm or more on the face mask area; poorly differentiated

Blue dye

18/20 (90%)

3/18 (17%)

0/15 (0%) NA

Altinyollar et al. 45

15 (NA) NA

Civantos et al. 46

Planar lymphoscintigraphy + Gamma probe

15/15 (100%)

1/15 (7%)

0/14 (0%) Median 14 (range 9 – 30)

Demir et al. 47

14 (11)

Median 65 (range 52 – 82)

Planar lymphoscintigraphy + Gamma probe + Blue dye

14/14 (100%)

0/14 (0%)

0/14 (0%) Median 38.5 (range 7 – 69)

53 (44)

Mean 73 (range 47 – 90)

SPECT/CT + Gamma probe + Blue dye

50/53 (94%)

6/50 (12%)

5/44

Median 25.5 (range, 2 – 57)

Durham et al. 48

(11%)

Foy et al. 49

Median 72 (39 – 80) NCCN guidelines version 2.2012

19 (16)

Planar lymphoscintigraphy + Gamma probe Planar lymphoscintigraphy + Gamma probe Planar lymphoscintigraphy + Gamma probe + Blue dye SPECT/CT and/or Planar lymphoscintigraphy + Gamma probe

18/19 (95%)

1/18 (5%)

2/17

Mean51.7 (NA)

(12%)

63 (41)

Median 73.2

At least two of: tumor diameter ≥ 10 mm; thickness ≥ 4 mm; specific tumor location

Ilmonen et al. 50

63/63 (100%)

4/63 (6%)

5/59 (9%) Median 49.2 (range 2.4 – 165.6) NA Mean 110.4 (84 – 132)

(range 40.1 – 91)

64 (40)

Mean 71.5 (range 58 – 84)

NCCN guidelines version 2007

64/64 (100%)

14/64 (22%)

Jankovi c et al. 51

Jansen et al. 52

87 (NA) NA

Tumor thickness >4 mm or at least three of: tumor thickness >2 mm; specific tumor sites; poor differentiation; PNI

87/87 (100%)

3/87 (3%)

0/84 (0%) NA

(Continues)

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