FLEX November 2023

2292 COSTANTINO ET AL .

TABLE 1

(Continued)

SLN identification (%)

SLNB positive rate (%)

RRR (%)

Study

N (male) Age (range)

Criteria for high risk

SLNB technique

FU (months)

Klode et al. 53

19 (NA) NA

Tumor thickness >4.0 mm

SPECT/CT + Gamma probe

17/19 (89%)

0/17 (0%)

0 /17

NA

(0%)

Krediet et al. 54 8 (7)

Median 68.5 (range 66 – 83)

At least three of: tumor diameter ≥ 20 mm; specific tumor site; recurrent tumor;

Planar lymphoscintigraphy + Gamma probe + Blue dye

8/8 (100%)

0/8 (0%)

3/8 (38%) NA

immunosuppression; moderate or poor differentiation; and tumor thickness ≥ 4 mm or Clark Level ≥ 4 Deep dermis infiltration; poor differentiation; tumor diameter ≥ 10 mm At least one of: tumor size >2 cm; invasion into subcutaneous fat (Clark level 5) or depth of invasion >5 mm; poor differentiation; PNI; ALI; recurrent tumor; tumor specific location; immunosuppression; site of a scar Specific tumor site; tumor size >2 cm; depth of invasion >4 mm; moderate or poor differentiation; PNI; recurrent tumors AreaL ≥ 20 mm; area M ≥ 10 mm; areaH ≥ 6 mm; poorly defined borders; recurrent tumor; immunosuppression; prior RT; moderate or poor differentiation; Clark Level ≥ 4; PNI; ALI At least 1 risk factor: size >10 mm on the head; size >6 mm on the face; poorly defined borders; recurrent lesion; immunosuppression; site of prior RT or chronic inflammatory process; rapid growth

Michl et al. 55

5 (3)

Median 72 (range 54 – 79)

Planar lymphoscintigraphy + Gamma probe + Blue dye Planar lymphoscintigraphy + Gamma probe + Blue dye

5/5 (100%)

0/5 (0%)

0/5 (0%) NA

104 (90) Mean 65 (range 27 – 90)

Mooney et al. 56

99/105 (94%)

10/99 (10%)

5/89 (6%) Mean 26.2 (range 1 – 60)

11 (NA) Median 75 (range 59 – 90)

Planar lymphoscintigraphy + Gamma probe + Blue dye

11/11 (100%)

1/11 (9%)

2/10

Median24 (range 2 – 38)

Rastrelli et al. 57

(20%)

33 (NA) NA

Planar lymphoscintigraphy + Gamma probe

33/33 (100%)

0/33 (0%)

0/33 (0%) NA

Samsanavic ˇ ius et al. 58

5 (3)

Median 72 (range 47 – 77)

Takahashi et al. 59

Planar lymphoscintigraphy + Gamma probe

5/5 (100%)

0/5 (0%)

0/33 (0%) Median 37 (range 31 – 47)

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