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et al. 32 RCT KTP 8 68 15 100 0.5 6.3 3.1 2.8 2.3 NR NR 0 NR NR NR KTP yielded signi fi cantly reduced VHI scores compared to TLM-CO2. No relapse et al. 29

demonstrated excellent oncologic outcomes when close surveillance and proactive retreatments were utilized. Disease-speci fi c survival, overall survival,

rate (%) Conclusion

curative outcome as CO2 cordectomy but may allow for better preservation of vocal fold ’ s architecture and function.

achieved acceptable local control and postoperative voice comparable to those with a CO2 laser reported in the literature.

laser salvage treatment of early glottic cancer is an effective treatment after failed irradiation.

using a KTP laser is a viable treatment option. It has a learning curve and a

failure rate but, in this series, no ultimate loss of oncologic control.

and vocal function were excellent.

with ultra-narrow margins is an effective oncologic treatment strategy.

Radiotherapy was preserved for future use in more than 90% of patients.

primary radiation therapy in oncologic outcomes for T1 glottic squamous cell carcinoma.

occurred after KTP in contrast to one recurrence after TLM-CO2 within 6months.

Retrospective cohort KTP 47 NR NR 2.5 1.44 NR NR NR NR 12.70 10.60 88 98 KTP laser ablation is a modality equivalent to

Barbu et al. 6 Retrospective cohort KTP 20 NR NR 1.6 NR NR NR NR 20 20 NR 80 Preliminary evidence that angiolytic KTP Lahav Murono et al. 27

Retrospective cohort KTP 26 68.9 10.1 95 2.5 1.7 NR 6.4 9.1 NR 1.3 1.0 57 35 53.50 88 Ablating dysplasia and early glottic cancer

Retrospective cohort KTP 24 73 6.8 NR 1.6 0.5 NR NR NR 6.2 0.059 8 8.30 NR NR KTP laser for early glottic carcinoma

Retrospective cohort KTP 117 NR NR 2.2 NR NR NR NR 0.085 4 0.8 NR KTP laser removal of early glottic cancer

et al. 30 RCT KTP 12 71.08 8.47 NR 4.39 1.38 11 9 4 3 NR NR 100 NR KTP ablation technique offers a similar

Retrospective cohort KTP 88 68 12 83 1.64 0.6 3.8 3.2 3.8 4.7 NR NR 2 2.20 100 92.30 KTP ablation of early glottic cancer

Overall

survival

Disease free

rate (%)

Re

treatment (%)

disease, n (%)

Recurrent

GRBAS>1y, mean (SD)

GRBAS 6m,

mean (SD)

TABLE I.

(SD)

VHI >1y, mean

(SD)

VHI 6m, mean

Characteristics and Summary of Included Studies.

in years,

Follow-up

mean (SD)

(%)

Male

(SD)

Age,

mean

size, n

Sample

Studies Design Groups

et al. 33

Nouraei et al. 31

et al. 28

Abbreviations: GRBAS, Grade severity of dysphonia Roughness-Breathiness-Asthenia-Strain; KTP, potassium-titanyl-phosphate; NR, not reported; RCT, randomized controlled trial; SD, standard deviation,

Ahmed

Parker

Strieth

Zeitels

VHI, Voice Handicap Index.

Laryngoscope 133: August 2023

Suppah et al.: KTP in Glottic Neoplasms

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