HSC Section 8_April 2017

Otolaryngology–Head and Neck Surgery 154(5)

Table 3. (continued)

Study

Outcome Measures

Hearing Result

Vertigo Result

Side Effects

Study Quality

Symptomatology, PTA Slight improvement of hearing only during the first 3 mo of treatment

6 of 7 during the first 3 mo of treatment noted improvement in vertigo frequency Improved dizziness in 71%, tinnitus in 72%, and headache in 92% In 18 of 20 who experienced relief, attack of vertigo did not occur in 12 Symptomatic improvement in the Me´nie`re’s symptoms reported by only 4 of 13 (63%) and vertigo relieved in 6 (31%)

Hypokalemia,

2b

Petermann et al (1982) 10

hyperuricemia

Kitahara et al (1982) 9

Symptomatology

None reported

5 of 51 with abdominal discomfort

2b

None reported

4

Yamazaki et al (1982) 23

Symptomatology, PTA, ECoG

2 had hearing improvement, 2 had hearing loss

Brookes and Booth (1984) 12

Symptomatology, PTA 3 of 13 noted gains but could be clearly substantiated in only 1

Side effects in 6 of 13 (46.2%); paraesthesias in 12 of 13; 4 with headaches, 3 with drowsiness, 1 with chest tightness

4

Symptomatology, PTA No positive effect on hearing

Significant decrease of vertigo

None reported

1a

van Deelen and Huizing (1986) 11

Not assessed

None reported

3b

PTA

In short term (2-6 wk), decrease of

Corvera and Corvera (1989) 24

average hearing loss observed with both chlorthalidone and acetazolamide; in the long term ( . 5 y), no preventive effect on deterioration of the hearing loss In 58 of 104 cases (55.8%), the ‘‘treatment was effective’’ Hearing improved in 35%, unchanged in 29%, worse in 22%, Improvement in 7 of 32 (22%); hearing deterioration ( . 10- dB loss) in 13 patients (41%); good control of tinnitus by in 21% 57 (39.3%) of 145 ears showed hearing and could not be classified by CHE guidelines in 14%

Raivio et al (1989) 20

PTA, glycerol test, and electronystagmography with caloric testing

In 46 of 104 (44.2%), the vertigo was not under control Vertigo control complete or substantial in 79%, limited or insignificant in 19%, and worse in 2% Vestibular symptoms in 80% of patients improved

2 with disabling hypotension

4

Santos et al (1993) 21

1985 CHE reporting guidelines, PTA

None reported

4

Kanda et al (1993) 14

1985 CHE reporting guidelines, PTA

None reported

4

Kakigi et al (1995) 26

PTA

None reported

None reported

4

(continued)

29