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Wise et al.

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Author Manuscript Author Manuscript Author Manuscript Author Manuscript TABLE VIII.F.3-1.

Evidence for various allergy testing techniques Study Year LOE Study design Study groups Clinical endpoint Conclusion Nevis et al. 830 2016 1a Systematic review AR SPT accuracy Various factors determine SPT accuracy.

de Vos et al. 931 2013 1b Validating cohort AR and asthma Concordance of SPT and serology SPT and serology are discordant. Sharma et al. 932 2008 1b Validating cohort Mouse allergy RAST vs SPT vs intradermal test Sensitivity and specificity differ across tests.

Carr et al. 939 2005 1b Prospective controlled trial AR Evaluation of 8 devices for skin testing Consensus guidelines on skin testing. Wood et al. 793 1999 1b Validating cohort Cat allergy RAST vs SPT vs intradermal test Sensitivity and specificity differ across tests. Nelson et al. 937 1998 1b Validating cohort All subjects Wheal and flare of various devices. Results of SPT depend on device, technique, and control reagents chosen. Nelson et al. 856 1996 1b Validating cohort AR to grass Intradermal test vs challenge Positive intradermal test may not be relevant if SPT negative. Adinoff et al. 948 1990 1b Validating cohort AR SPT results SPT is accurate for various aeroallergens.

Jung et al. 792 2010 1c All or none case series HDM allergies ImmunoCAP versus SPT Sensitivity and specificity depend on patient demographics. Gendo & Larson 930 2014 2a Systematic review AR Utility of allergy testing History and pretest probability determine allergy testing utility. Haxel et al. 947 2016 2b Retrospective cohort AR Nasal challenge vs SPT vs RAST Nasal challenge should be performed to confirm eligibility for HDM AIT.

Tantilipikorn et al. 949 2015 2b Individual cohort AR Intradermal test vs serum sIgE Intradermal testing has higher sensitivity and lower specificity than sIgE for HDM.

Tversky et al. 928 2015 2b Individual cohort All subjects Wheal and flare of various devices Results of SPT depend on device, technique, and control reagents chosen. Choi et al. 943 2005 2b Retrospective cohort HDM allergy RAST vs SPT IgE cutoff level determine sensitivity and specificity. McCann & Ownby 942 2002 2b Individual cohort AR SPT measurements SPT results are not reproducible across centers. Pastorello et al. 946 1995 2b Exploratory case-control AR ImmunoCAP vs SPT Specific IgE accuracy depend on cutoff values.

Westwood et al. 794 2016 3a SR AR Microarray results Utility and cost of microarray testing needs further validation. Mucci et al. 791 2011 3a SR AR Review of AR Review of AR diagnosis and treatment. AIT = allergen immunotherapy; AR = allergic rhinitis; HDM = house dust mite; IgE = immunoglobulin E; LOE = level of evidence; RAST = radioallergosorbent test; sIgE = allergen-specific IgE; SPT = skin-prick test.

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.