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Postnasal dri p and postnasal dri p-related cough Yu and Becker

21. Irwin RS, French CL, Curley FJ, et al. Chronic cough due to gastroesophageal reflux. Clinical, diagnostic, and pathogenetic aspects. Chest 1993; 104:1511–1517. 22. Irwin RS. Chronic cough due to gastroesophageal reflux disease: ACCP evidence-based clinical practice guidelines. Chest 2006; 129 (1 Suppl):80S–94S. 23. Bernstein JA. Nonallergic rhinitis: therapeutic options. Curr Opin Allergy Clinical Immunol 2013; 13:410–416. 24. & Plonk DP, Luong A. Current understanding of allergic fungal rhinosinusitis and treatment implications. Curr Opin Otolaryngol Head Neck Surg 2014; 22:221–226. Sinus surgery should be considered in PND caused by sinusitis if imaging reveals inspissated mucus, fungal elements, or other disease findings of the paranasal sinuses. 25. & Maniscalco M, Faraone S, Sofia M, et al. Extended analysis of exhaled and nasal nitric oxide for the evaluation of chronic cough. Respir Med 2015; 109:970–974. PND remains a clinical diagnosis; however, use of nasal nitric oxide may be able to better distinguish PND from other causes of cough such as CVA and GERD.

26. & Pullerits T, Ternesten-Hasseus E, Johansson EL, Millqvist E. Capsaicin cough threshold test in diagnostics. Respir Med 2014; 108:1371–1376. Capsaicin inhalational testing has been used to evaluate for cough hypersensitivity in chronic cough patients. However, diagnostic testing with this modality remains limited because of a wide normal range in the population. 27. & Mincheva RK, Kralimarkova TZ, Rasheva M, et al. A real–life observational pilot study to evaluate the effects of two-week treatment with montelukast in patients with chronic cough. Cough 2014; 10:2. The use of montelukast with regards to chronic cough such as in PND may improve cough symptoms and although is not in current guidelines, further studies may change future recommendations. 28. & Ternesten-Hasseus E, Johansson EL, Millqvist E. Cough reduction using capsaicin. Respir Med 2015; 109:27–37. Capsaicin is showing promise as a method of decreasing cough hypersensitivity through desensitization therapy. 29. & Gevorgyan A, Segboer C, Gorissen R, et al. Capsaicin for nonallergic rhinitis. Cochrane Database Syst Rev 2015; 7:CD010591. Capsaicin is showing promise as a method of decreasing cough hypersensitivity through desensitization therapy.

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