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Wise et al.

Page 355

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Study Year LOE Study design Study groups Clinical endpoint Conclusion Kniest et al. 1121 1992 2b Double-blind matched pair controlled trial

Acaricide associated with improvement in all outcome measures except for mite-specific IgE.

HEPA filtration had no significant effect on rhinitis symptom scores.

HEPA filtration is associated with improved particulate counts and symptom/medication scores.

Daily symptoms and medication scores, physician assessment, tIgE, sIgE, serum and nasal

eosinophils, guanine exposure

HDM concentration, rhinitis and asthma symptom score

Particulate counts in bedroom air, symptom and medication scores, patients’ subjective response to treatment

2 Adults with atopy and placebo filtration

1 Adults and children with atopy and intensive home cleaning plus acaricide;

2 Adults and children with atopy and intensive home cleaning alone

1 Adults and children with atopy and HEPA filtration;

2 Adults and children with atopy without HEPA filtration

1 Adults with atopy and HEPA filtration;

crossover study

crossover RCT

1991 2b Randomized

Reisman et al. 1123 1990 2b Double-blind

Antonicelli et al. 1125

HDM = house dust mite; HEPA = high-efficiency particulate air; IgE = immunoglobulin E; LOE = level of evidence; PAF = personal air filtration; PEF = peak expiratory flow; QOL = quality of life; RCT = randomized controlled trial; RDBPCT = randomized double-blind-placebo-controlled trial; RQLQ; Rhinoconjunctivitis Quality of Life Questionnaire; sIgE = antigen specific immunoglobulin E; SR = systematic review; tIgE = total immunoglobulin E.

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.