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Wise et al.

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Author Manuscript Author Manuscript Author Manuscript Author Manuscript TABLE IX.B.8-1.

Evidence for the use of nasal saline in the treatment of allergic in adults Study Year LOE Study design Study groups Clinical endpoint Conclusion Hermelingmeier et al. 1416 2012 1a SR and meta analysis SAR and PAR, adults and children Nasal symptom score, medicine use, QOL Nasal symptoms and medicine use decreased with the use of nasal saline. Adults benefit more than children. Chusakul et al. 1409 2013 1b DBRCT, crossover AR: 1 Non-buffered isotonic saline; 2 Buffered with mild alkalinity (pH 7.2–7.4); 3 Buffered with alkalinity (pH 8.2–8.4) Nasal symptom score Nasal symptoms were improved from baseline only by buffered saline with mild alkalinity. Garavello et al. 151 2010 1b RCT, no blinding SAR, pregnant women: 1 Hypertonic saline irrigations TID; 2 No irrigations Nasal symptom score, oral antihistamine use Hypertonic saline irrigations during pollen season improves nasal symptoms and decreases oral antihistamine use. Ural et al. 1408 2008 1b RCT, no blinding PAR: Mucociliary clearance time

Isotonic saline improved mucociliary clearance time.

RQLQ Dead Sea saline group had significant improvements but not as significant as

triamcinolone group; no change in placebo group.

The addition of hypertonic saline resulted in a significant improvement in symptoms and QOL.

Nasal symptoms, QOL (Rhinasthma questionnaire)

1 Hypertonic saline irrigations BID; 2 Isotonic saline irrigations BID

Cordray et al. 1406 2005 1b SBRCT SAR: 1 Dead Sea saline spray; PAR:

2 Triamcinolone spray;

3 Placebo nasal saline spray

1 Hypertonic saline spray QID + cetirizine; 2 Cetirizine only

blinding

Rogkakou et al. 1407 2005 1b RCT, no

AR = allergic rhinitis; BID = 2 times daily; DBRCT = double-blind randomized controlled trial; LOE = level of evidence; PAR = perennial allergic rhinitis; QID = 4 times daily; QOL = quality of life; RCT = randomized controlled trial; RQLQ = Rhinoconjunctivitis Quality of Life Questionnaire; SAR = seasonal allergic rhinitis; SBRCT = single-blind randomized controlled trial; SR = systematic review; TID = 3 times daily.

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.