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Wise et al.

Page 392

Author Manuscript Author Manuscript Author Manuscript Author Manuscript TABLE IX.B.8-2.

Evidence for the use of nasal saline in the treatment of allergic rhinitis in children Study Year LOE Study design Study groups Clinical endpoint Conclusion Hermelingmeier et al. 1416 2012 1a SR and meta analysis SAR and PAR, adults and children Nasal symptom score, medicine use, QOL Nasal symptoms and medicine use decreased with the use of nasal saline. Adults benefit more than children. Chen et al. 1415 2014 1b RCT, no blinding PAR: 1 Steroid nasal spray daily; 2 Seawater spray BID; 3 Both Nasal symptom score, nasal signs All groups improved. Steroid spray plus seawater had more significant improvements than other arms. Marchisio et al. 1413 2012 1b SBRCT SAR: 1 Hypertonic saline irrigations BID; 2 Normal saline irrigations BID; 3 No irrigations Nasal symptom score, turbinate and adenoid hypertrophy, oral antihistamine use Hypertonic saline was significantly more effective in improving symptom score, decreasing adenoid and turbinate hypertrophy, and decreasing duration of antihistamine use. Satdhabudha et al. 1114 2012 1b DBRCT AR: 1 Buffered hypertonic saline irrigations BID; 2 Normal saline irrigations BID TNSS, QOL (Rcq-36), oral antihistamine use Li et al. 1412 2009 1b RCT, no blinding PAR:

Greater improvement in symptoms with buffered hypertonic saline. No significant difference in QOL or antihistamine use at 4 weeks.

Nasal symptoms All groups improved. Steroid spray plus saline irrigations had more significant improvement than other arms. Nasal symptom score, oral antihistamine use

Hypertonic saline irrigations during pollen season had significant improvement in nasal symptoms and reduction in oral antihistamine use after 5 weeks.

Hypertonic saline irrigations during pollen season improves nasal symptoms and decreases oral antihistamine use.

Nasal symptom score, oral antihistamine use

1 Steroid nasal spray daily;

2 Isotonic nasal saline irrigations BID; 3 Both

1 Hypertonic saline irrigations TID; 2 No irrigations

1 Hypertonic saline irrigations TID; 2 No irrigations

SAR:

SAR:

blinding

blinding

Garavello et al. 1411 2005 1b RCT, no

Garavello et al. 1410 2003 1b RCT, no

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.