xRead - September 2022

Wise et al.

Page 394

Author Manuscript Author Manuscript Author Manuscript Author Manuscript TABLE IX.B.9.

Evidence for the use of probiotics in the treatment of allergic rhinitis Study Year LOE Study design Study groups Clinical endpoint Conclusion Guvenc et al. 1421 2016 1a SR and meta analysis SAR and PAR, adults and children. Daily probiotic vs placebo. 22 DBRCTs (n = 2242) Symptom scores, QOL, immunologic parameters 17 studies demonstrated clinical benefit of probiotics. Improvement in TNSS, TOSS, total QOL, nasal QOL, and ocular QOL. Zajac et al. 1420 2015 1a SR and meta analysis SAR and PAR, adults and children. Daily probiotic vs placebo. 21 DBRCTs and 2 crossover studies, (n = 1919) Validated QOL or symptom scores, immunologic parameters 17 studies demonstrated clinical benefit of probiotics. Improvement in RQLQ global and nasal symptom scores. Costa et al. 1425 2014 1b DBRCT SAR to grass pollen, adults (n = 425). Lactobacillus paracasei -33 × 5 weeks RQLQ, RTSS Probiotic improved RQLQ. Lin et al. 1434 2014 1b DBRCT PAR to HDM, children (n = 60). Lactobacillus paracasei HF.A00232 × 8 weeks RTSS, PRQLQ Probiotic improved PRQLQ, sneezing, ocular itching/swelling at 12 weeks. Dolle et al. 1445 2013 1b DBRCT SAR to grass pollen, adults (n = 34). Escherichia coli Nissle 1917 × 6 months Symptom-medication score No benefit. Lin et al. 1426 2013 1b DBRCT PAR to HDM, children (n = 199). Lactobacillus salivarius × 12 weeks Specific symptom score, symptom-medication score, tIgE Probiotic improved nasal, eye, medication scores. TNSS Probiotic improved TNSS. crossover No benefit.

RTSS, PRQLQ Probiotic improved RTSS.

symptoms.

Probiotic improved symptom medication score and ocular itching.

Probiotic improved symptom medication score.

Probiotic improved nasal blockage and medication score.

SCORing Allergic Rhinitis Index: specific symptom

score, symptom-medication score, tIgE, blood eosinophil count

Subjective symptoms, tIgE Probiotic decreased nasal Symptom-medication score, tIgE, sIgE Symptom-medication score, RQLQ, tIgE, sIgE, blood eosinophil count, Th1:Th2 ratio Mean symptom score, mean symptom-medication score, tIgE, sIgE

Kawase et al. 1427 2009 1b DBRCT SAR to JCP, adults (n = 40). Lactobacillus GG and L. gasseri TMC0356 × 10 weeks

Singh et al. 1441 2013 1b DBRCT SAR to grass pollen, adults (n = 20). Bifidobacterium lactis NCC2818 × 8 weeks Lue et al. 1422 2012 1b Randomized

Nagata et al. 1431 2010 1b DBRCT SAR to JCP, adults (n = 55). Lactobacillus plantarum #14 × 6 weeks

Chen et al. 1432 2010 1b DBRCT SAR and PAR, children (n = 105). Lactobacillus gasseri A5 × 8 weeks

Jan et al. 1438 2011 1b DBRCT PAR to HDM, children (n = 240). Lactobacillus gasseri × 12 weeks

Gotoh et al. 1439 2009 1b DBRCT SAR, adults (n = 107). Lactobacillus gasseri × 8 weeks

PAR, children (n = 63). Lactobacillus johnsonii EM1

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.