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Wise et al.

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Author Manuscript Author Manuscript Author Manuscript Author Manuscript TABLE IX.C.

Evidence for surgery in the treatment of allergic rhinitis Study Year LOE Study design Study groups Clinical endpoint Conclusion Jose & Coatesworth 2 2010 1a SR of RCTs Turbinate reduction in refractory AR No studies qualified as RCT No conclusions could be made. Chen et al. 1557 2008 1b RCT AR patients undergoing IT: 1 Microdebrider submucous resection; 2 Bony resection VAS, anterior rhinomanometry, saccharin transit time Significant improvement in all parameters for both treatment groups at 1, 2, and 3 years. Passali et al. 1236 1999 2b RCT AR patients undergoing IT: 1 Electrocautery; 2 Cryotherapy; 3 Laser ablation; Rhinomanometry, acoustic rhinometry, mucociliary transport time, secretory IgA levels, symptom scores Submucosal resection with lateral displacement of the IT results in the

greatest increase in nasal airflow and nasal respiratory function with the lowest risk of long-term complications.

QOL outcomes All subjects improved, but improvement in vidian neurectomy group exceeded group undergoing turbinectomy and/or septoplasty.

Significant improvement in both groups but less obstruction in septoplasty group.

Non-AR subjects showed more improvement than AR subjects.

Significant improvement seen at 1 and 3 years.

Rhinomanometry and VAS Objective and subjective improvement up to 2 years.

Statistically significant reductions were noted in the angle and distances in all sections.

Mean rescue medication score, Rhinasthma Questionnaire

Karatzanis et al. 1554 2009 3b Case-control Septoplasty in patients with or without AR NOSE scores, anterior rhinomanometry Mori et al. 1556 2002 3b Observational cohort rhinometry, nasal challenge

Caffier et al. 1558 2011 4 Case series AR patients undergoing mucosal laser reduction, 95% to IT Aksoy et al. 1564 2010 4 Case series AR patients undergoing IT outfracture CT sinus preoperatively, and 1 and 6 months postoperatively

4 Submucosal resection without lateral displacement;

1 Vidian neurectomy;

2 Turbinectomy and/or septoplasty; 3 Medical treatment

1 Septoplasty with IT turbinoplasty; 2 IT turbinoplasty alone

5 Submucosal resection with lateral displacement; 6 Turbinectomy

AR patients undergoing:

Kim et al. 1555 2011 3b Case-control AR patients undergoing:

AR patients undergoing IT submucous turbinectomy Standard symptom score,

cohort

Tan et al. 1566 2012 3b Observational

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.