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Wise et al.

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Author Manuscript Author Manuscript Author Manuscript Author Manuscript TABLE X.A.2.

Evidence for the association between asthma, allergic rhinitis and non-allergic rhinitis Study Year LOE Study design Study groups Clinical endpoint Conclusion Ohta et al. 1754 2011 3b Case series Asthmatic patients (n = 26,680) Rhinitis and asthma diagnosis Rhinitis is common in asthma and impairs asthma control. Valero et al. 1756 2009 3b Case series Patients with AR (n = 3225) Rhinitis comorbidities Asthma was influenced by skin sensitization and severity of AR. Ponte et al. 1755 2008 3b Case series Patients with severe asthma (n = 557) Asthma severity Moderate/severe rhinitis is a strong predictor for greater severity of asthma. Bousquet et al. 25 2005 3b Case-control Patients consulting ENT and allergy specialists for AR (n = 591) vs controls (n = 502) Presence of asthma Asthma prevalence increases with duration and severity of rhinitis. Leynaert et al. 1753 2004 3b Cohort International cross-sectional study of representative samples of young adults (n = 3000) Rhinitis and asthma diagnosis Association between asthma and rhinitis was not fully explained by atopy. Linneberg et al. 1752 2002 3b Cohort Follow-up on 2 occasions 8 years apart (n = 734) Rhinitis and asthma in patients sensitized to pollen AR and allergic asthma are manifestations of the same disease. Bresciani et al. 1757 2001 3b Case series Patients with severe steroid-dependent asthma (n = 35) Sinonasal disease Frequency of rhinosinusitis in patients with mild-to moderate or severe steroid-dependent asthma is similar.

AR = allergic rhinitis; ENT = ear, nose and throat; LOE = level of evidence.

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.