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Wise et al.

Page 436

SLIT administered as sublingual drops of standardized allergen for a buildup phase and then continued for maintenance phase. AR = allergic rhinitis; BHR = bronchial hyper-responsiveness; DBRCT = double-blind randomized controlled trial; HDM = house dust mite; IgE = immunoglobulin E; LOE = level of evidence; PC 20 and PD 20 = provocation “concentration” or “dose” of methacholine causing a 20% decrease in FEV1 (also described as PD 20 FEV 1 ); RCT = randomized controlled trial; SCIT = subcutaneous immunotherapy; SLIT = sublingual immunotherapy; SR = systematic review; VAS = visual analogue scale.

Author Manuscript Author Manuscript Author Manuscript Author Manuscript

Study Year LOE Study design Study groups Clinical endpoint Conclusion 2 Medication only a

Strength of evidence moderate to high, for asthma-focused studies and rhinitis-focused studies, respectively. b The strength of evidence is moderate for both comparisons. c

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.