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Wise et al.

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Author Manuscript Author Manuscript Author Manuscript Author Manuscript TABLE X.B-1.

Evidence for an association between allergic rhinitis and acute rhinosinusitis Study Year LOE Study design Study groups Clinical endpoint Conclusion Rantala et al. 1856 2013 2a Cross-sectional Atopic and nonatopic adults age 21-63 years (n = 1008) Upper and lower respiratory tract infections Individuals with atopic disease had higher risk of developing URTI, including RS. Chen et al. 1848 2001 2a Questionnaire Children in Taiwan (n = 8723) Rhinosinusitis Children reporting allergy are more likely to have RS. = 102) Prevalence of AR Orbital complications are more common in allergy season. Frerichs et al. 1857 2014 3a SR Allergic and non-allergic patients Prolonged course (>4 weeks) of RS No significant increase in prolonged RS in AR patients. Savolainen 1847 1989 3b Case-control Acute maxillary sinusitis with and without allergy (n = 224) ARS Prevalence of AR 25% and 16.5% in non-AR patients.

Holzmann et al. 1849 2001 2b Retrospective review Children with orbital complications of ARS (n

AR = allergic rhinitis; ARS = acute rhinosinusitis; LOE = level of evidence; RS = rhinosinusitis; SR = systematic review; URTI = upper respiratory tract infection.

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.