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Wise et al.

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Author Manuscript Author Manuscript Author Manuscript Author Manuscript TABLE X.B-2.

Evidence for an association between allergic rhinitis and recurrent acute rhinosinusitis Study Year LOE Study design Study groups Clinical endpoint Conclusion Melvin et al. 1853 2010 2b Prospective cohort (n = 21): 1 Allergic patients with RS; 2 Allergic-only patients Expression of TLR9 in sinonasal epithelium Increased expression of TLR9 in allergic patients with RS. Kalfa et al. 1852 2004 2b Cross-sectional (n = 47): 1 Allergic patients with RS; 2 Allergic-only patients; 3 Non-allergic controls Nasal secretion levels of EDN and lysozyme levels Allergic patients with RS have elevated levels of EDN and decreased lysozyme levels.

EDN = eosinophil-derived neurotoxin; LOE = level of evidence; RS = rhinosinusitis; TLR9 = toll like receptor 9.

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.