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Wise et al.

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Author Manuscript Author Manuscript Author Manuscript Author Manuscript TABLE X.B-3.

Allergic patients had higher CT scores and higher incidences of S. aureus sensitization.

Evidence for allergic rhinitis and chronic rhinosinusitis without nasal polyposis Study Year LOE Study design Study groups Clinical endpoint Conclusion Baroody et al. 1844 2008 1b RCT CRSsNP with or without ragweed allergy (n = 18) Reactivity in ragweed season determined by symptoms and sinus inflammation Allergic patients have increased reactivity and sinonasal inflammation in ragweed season. Wilson et al. 1854 2014 3a SR CRSsNP with or without allergy Association between CRSsNP and allergy Conflicting evidence with no clear association. Tan et al. 1858 2011 3b Prospective case control CRSsNP with or without allergy (n = 63) (72% in rhinitis, 79% in CRSsNP). Pearlman et al. 1859 2009 3b Prospective case series CRSsNP with or without allergy (n = 115) CT scores No difference in CT scores. Gelincik et al. 1860 2008 3b Prospective case series CRSsNP with or without allergy (n = 66) Prevalence of CRSsNP in allergic and non-allergic rhinitis patients CRSsNP was equally prevalent in allergic (43%) and non-allergic (50%) rhinitis patients. Kirtsreesakul & Ruttanaphol 1861 2008 3b Retrospective case series CRSsNP with or without allergy (n = 198) Sinus X-rays, nasal endoscopy Allergic patients had a higher incidence of abnormal sinus X-rays. Robinson et al. 1862 2006 3b Prospective case series CRSsNP with or without allergy (n = 193) Lund-Mackay CT scores and symptoms scores Alho et al. 1863 2004 3b Prospective case series CRSsNP with or without allergy (n = 48) CT findings during viral URTI, incidence of S. aureus sensitization Van Zele et al. 1864 2004 3b Prospective case control CRSsNP with or without allergy (n = 31) Rates of S. aureus colonization No difference in colonization rates. Berrettini et al. 1865 1999 3b Prospective case control CRSsNP with or without allergy (n = 77) Rates of atopy in rhinitis vs CRSsNP No significant difference in rates of atopy CT scan findings, nasal endoscopy, nasal swabs, rhinomanometry Allergy was not associated with CT findings or symptoms scores.

Increased CT evidence of sinusitis in allergy (68%) vs non-allergic (33%) patients.

CRSsNP = chronic rhinosinusitis without nasal polyposis; CT = computed tomography; LOE = level of evidence; RCT = randomized controlled trial; SR = systematic review; URTI = upper respiratory infection.

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.