xRead - September 2022

Wise et al.

Page 440

Author Manuscript Author Manuscript Author Manuscript Author Manuscript TABLE X.B-4.

Evidence for allergic rhinitis and chronic rhinosinusitis with nasal polyposis Study Year LOE Study design Study groups Clinical endpoint Conclusion Houser & Keen 1866 2008 2b Retrospective case series CRSwNP with or without allergy (n = 373) Nasal polyposis AR is associated with the development of nasal polyposis. Wilson et al. 1854 2014 3a Systematic review CRSwNP with or without allergy Association between CRSwNP and allergy Conflicting evidence with no clear association. Al-Qudah 1867 2016 3b Prospective cohort study CRSwNP compared to CRSsNP (n = 155) Rates of food sensitivity No difference between allergic and non allergic patients. Li et al. 1855 2016 3b Prospective cohort CRSwNP with or without allergy (n = 210) Nasal endoscopy, CT scores, serum inflammatory markers No difference in allergic and non-allergic patients. Gorgulu et al. 1868 2012 3b Prospective case-control CRSwNP compared to controls (n = 60) Rate of allergen sensitivity No difference between allergic and non allergic patients. Lill et al. 1869 2011 3b Prospective case-control CRSwNP compared to controls (n = 50) Rates of food sensitivity Higher rate of milk sensitivity in CRSwNP. Tan et al. 1858 2011 3b Prospective case-control CRSwNP with or without allergy (n = 62) Rates and number of antigen sensitivity No difference in rates of sensitivity. Munoz del Castillo et al. 1870 2009 3b Prospective case-control CRSwNP compared to controls (n = 190) Rates of allergy compared to control Higher rates of allergy in CRSwNP compared to controls. Collins et al. 1871 2006 3b Prospective case-control CRSwNP compared to controls (n = 40) Rates of food sensitivity Higher rates of food sensitivity in CRSwNP. Van Zele et al. 1864 2004 3b Prospective case-control CRSwNP compared to CRSsNP and controls (n = 55) Rates of S. aureus colonization Higher rates of colonization in CRSwNP. Kirtsreesakul 1872 2002 3b Prospective cohort CRSwNP with or without allergy (n = 68) Response to budesonide nasal sprays (sneezing, oral and nasal peak flow, overall response to therapy) Improved response in non-allergic patients. Rates of Candida and house dust sensitivity

Higher rates of sensitivity in CRSwNP.

Higher rates of asthma in allergic patients.

Rates of Candida sensitivity Higher rates of sensitivity in CRSwNP. Rates of food sensitivity Higher rates of food sensitivity in CRSwNP. Incidence of house dust and cockroach allergy

Higher rates of allergy in CRSwNP compared to controls.

No difference except in patients with ragweed allergy. Ragweed-positive

Rates of asthma in allergic or non allergic patients

Symptom scores, serum levels of inflammatory markers

Asero & Bottazzi 1874 2001 3b Prospective case-control CRSwNP compared to non-polyp controls (n = 68)

Voegels et al. 1873 2001 3b Prospective case-control CRSwNP with or without allergy (n = 39)

Asero & Bottazzi 1875 2000 3b Prospective case-control CRSwNP compared to allergic controls (n = 20)

Pang et al. 1876 2000 3b Prospective case-control CRSwNP compared to controls (n = 80)

Pumhirun et al. 1877 1999 3b Prospective case-control CRSwNP compared to controls (n = 40)

Keith et al. 1878 1994 3b Prospective case-control CRSwNP with or without allergy (n = 64)

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.