xRead - September 2022

Wise et al.

Page 444

Author Manuscript Author Manuscript Author Manuscript Author Manuscript

Prevalence of AD: 48%. SPT positive for HDM in 85%. Children with AR and concomitant AD show preferential sensitization to Dermatophagoides mites.

Study Year LOE Study design Study groups Clinical endpoint Conclusion Questionnaire, physical examination, SPT.

Prevalence of rhinitis in the last 12 months: 16.8%. Rhinitic children had significantly more AD (22.9% vs 13.9%, p < 0.001).

Prevalence of physician-diagnosed AR: 17%. Prevalence of physician-diagnosed eczema: 4.9%. Atopic sensitization prevalence: 8.8%; HDM sensitization most frequent.

Prevalence of ever rhinitis: 36.3%, current rhinitis: 30.6%, ever hay fever: 8.3%. SPT positivity: 20.4% among children with current rhinitis. Flexural dermatitis significantly associated with current rhinitis.

Lifetime cumulative prevalence of AD symptoms: 1.2%. AD symptoms strongly associated with rhinitis symptoms (OR, 61.94; 95% CI, 42.66–89.95).

Prevalence of AD peaked at 20% of children by 1 year of age, declined to 5% at end of the study. AR prevalence slowly increased over time from 3% to 15%.

Prevalence of PAR in tertiary referral hospitals in Korea is 3.93%. Associated atopic dermatitis in 20.9% subjects with PAR.

AD improved in 84 of 92 children; 45% developed AR. Severity of AD was a risk factor for subsequent development of AR. Consistent with atopic march.

Eczema rate: 5.4% among females, 6.3% among males. Rhinitis symptoms: 11.1% among females, 8.9% among males.

19.9% suffered from rhinoconjunctivitis, and 0.8% AD.

Hay fever prevalence: Hong Kong 15.7%; Kota Kinabalu 11.2%; San Bu 2.1%. Eczema prevalence: Hong Kong 20.1%; Kota Kinabalu 7.6%; San Bu 7.2%.

Prevalence and etiologic factors of asthma, rhinitis, and eczema. Questionnaire, SPT (subset), flexural dermatitis.

Questionnaire, SPT (subset). Prevalence of AD symptoms, association with rhinitis symptoms. Questionnaire, SPT.

Comparison of disease associations between rhinitic and non-rhinitic children.

Examination, SPT, tIgE, bronchial hyper-responsiveness to inhaled histamine. Development of AR and asthma

Questionnaire, examination, SPT, serum allergy test.

tIgE, sIgE, SPT. Evaluation of development of AR and asthma.

Questionnaire, physical examination and SPT (subset).

Determine prevalence of asthma, AR, AD.

Evaluation of prevalence of atopic disease.

Questionnaire, SPT (subset). Evaluation of prevalence of

asthma and allergic disease.

Questionnaire, SPT. Relative risk of sensitization and associated risk factors.

Karaman et al. 1908 2006 3b Cross-sectional n = 1217 children in 3rd, 4th, and 5th grade in Izmir, Turkey; response rate 57.6%. ISAAC II methodology.

Kuyucu et al. 556 2006 3b Cross-sectional n = 2774 Turkish school children aged 9-11 years; response rate:

89.2%. ISAAC II questionnaire.

Yemaneberhan et al. 1911 2004 3b Cross-sectional n = 12,876 participants; 95% of those eligible took part in the survey. cohort

Peroni et al. 636 2003 3b Cross-sectional n = 1402 preschool children age 3-5 years; response rate: 92%. ISAAC questionnaire.

n = 100 infants from atopic families followed for 22 years; 63% retained at last follow-up.

Min et al. 1912 2001 3b Cross-sectional n = 71,120 randomly selected subjects from Korean otolaryngology clinics Gustafsson et al. 1899 2000 3b Longitudinal cohort

n = 94 children with AD followed for 8 years

Ozdemir et al. 1913 2000 3b Cross-sectional n = 1603 college students in Eskisehir, Turkey; 94.5% response rate.

Garcia-Gonzalez et al. 1914 1998 3b Cross-sectional n = 365 students from Malaga, Spain Interview, SPT, tIgE, sIgE. Leung & Ho 1915 1994 3b Cross-sectional n = 2208 secondary school students; response rate over 87%. Kidon et al. 1910 2005 4 Prospective case series n = 175 newly diagnosed AR patients; predominantly Chinese; mean age 7.9 years.

Rhodes et al. 1898 2002 3b Longitudinal

AD = atopic dermatitis; AR = allergic rhinitis; HDM = house dust mite; IgE = immunoglobulin E; ISAAC = International Study of Asthma and Allergies in Childhood; LOE = level of evidence; OR = odds ratio; CI = confidence interval; PAR = perennial allergic rhinitis; SAR = seasonal allergic rhinitis; sIgE = antigen-specific immunoglobulin E; SPT = skin-prick test; tIgE; total immunoglobulin E.

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.