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Wise et al.

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Author Manuscript Author Manuscript Author Manuscript Author Manuscript TABLE X.G-2. Study

design Study groups Clinical endpoint Conclusion

History, SPT AR was present in 28% of OME group vs 24% of control. SPT and tympanogram for all subjects

Equal rates of sensitization between OME group and controls.

Chantzi et al. 1961 2006 3b Case-control 1 OME (n = 88 children); 2 Controls (n = 80 children) Allergy history and tests IgE sensitization is independent risk factor for OME. Corey et al. 1964 1994 3b Case-control 1 OME (n = 89 children); 2 Controls (n = 59 children)

RAST Positive RAST: 61% in OME group vs 41% in controls Borge 1963 1983 3b Case-control 1 Serous OM (n = 89); 2 Controls (n = 67)

Allergy history and testing 41% of serous OM patients had perennial rhinitis vs 11% of controls.

39% of cohort had OME. OR of 3.36 for AR and OME.

100% of OME had positive allergy tests; 85% of AIT treated patients cured.

57% with positive SPT, almost all with rhinitis.

Allergy tests, effusion, ECP Allergies in 97% of COME.

AIT or food elimination diet All patients treated with AIT or food elimination resolved. 17% control.

23% of allergic OME patients had evidence of local IgE. Higher levels of IgE in MEE of allergic children.

Kreiner-Moller et al. 1965 2012 4 Case series 6-year-old children (n = 262) Assessment for OME and allergy

Resolution of effusion or drainage at 2-year to 8-year follow-up

Alles et al. 1969 2001 4 Cohort 3-year-old to 8-year-old children with OME Assessment of AR, asthma, eczema

Tomonaga et al. 1962 1988 4 Cohort 259 children with OME; 605 nasal allergy; 104 controls Allergy testing; tympanometry 50% of OME cases had nasal allergy vs Bernstein et al. 1956 1985 4 Cohort 100 patients with OME: 35 allergic, 65 non-allergic Total and specific IgE in MEE and serum Bernstein et al. 1957 1983 4 Cohort 77 children with recurrent OME and history of myringotomy tubes Allergy evaluation, serum, nasal, MEE total IgE

1 OME (n = 123 children);

2 Controls (n = 141 children)

1 AR and OME (n = 172, 4-14 years); 2 Controls (n = 200)

Hurst 1966 2008 4 Cohort 1 OME patients treated with AIT (n = 89); Hurst 1967 1996 4 Cohort 1 OME (n = 73); 2 Controls (n = 16) 2 OME patients not treated with AIT (n = 21)

Hurst 1968 1990 4 Cohort 20 OME patients, all allergic: 17 treated with AIT, 3 untreated controls

control

group

control

group

Evidence for the role of allergic rhinitis in otitis media Study Year LOE Yeo et al. 1960 2007 2b Cohort with Caffarelli et al. 1959 1998 2b Cohort with

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.