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Wise et al.

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Author Manuscript Author Manuscript Author Manuscript Author Manuscript Study

Study Year LOE design Study groups Clinical endpoint Conclusion Bernstein et al. 1958 1981 4 Cohort 41 patients with OME: 20 allergic, 21 non-allergic Total and specific IgE in MEE and serum 15% of allergic OME cases had evidence of local IgE. McMahan et al. 1970 1981 4 Case series 119 COME patients RAST test 93% of COME positive to inhalant allergens.

AIT = allergen immunotherapy; AR = allergic rhinitis; COME = chronic otitis media with effusion; IgE = immunoglobulin E; LOE = level of evidence; MEE = middle ear effusion; OM = otitis media; OME = otitis media with effusion; OR = odds ratio; RAST = radioallergosorbent test; SPT = skin-prick test.

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.