xRead - September 2022

Wise et al.

Page 453

Author Manuscript Author Manuscript Author Manuscript Author Manuscript TABLE X.G-3. Study

design Study groups Clinical endpoint Conclusion 1 AR (n = 30);

Audiometry, OAE, ABR AR subjects had evidence of inner ear dysfunction.

Meniere’s patients are more likely to have positive allergy test. 41% Meniere’s patients had elevated total IgE.

Meniere’s disease patients have more AR and food allergy.

Serum total IgE No difference in serum total IgE between groups.

Allergy treatment reduced tinnitus and vertigo.

57% of subjects had >15% change in SP/AP ratio after challenge.

82% had normal serum IgE; AIT improved vertigo in 62%

6/27 intracutaneous food challenges had induction of aural symptoms and >15% change in SP/AP ratio.

Peripheral blood lymphocyte populations, cytokines, allergen specific and total IgE levels

Allergy symptoms, history questionnaire

Self-reported symptoms via post treatment survey

Gibbs et al. 1983 1999 4 Case series 7 patients with Meniere’s and inhalant allergy Change in ECoG after allergen challenge 1992 4 Cohort 93 Meniere’s disease patients with suspected allergy Intradermal test, in vitro allergy tests, serum IgE, provocative food testing, AIT response Viscomi & Bojrab 1984 1992 4 Cohort 5 patients with Meniere’s disease and AR Allergen challenge with intracutaneous provocative food test. >15% change in SP/AP ratio on ECoG, provocation of Meniere’s symptoms

2 Controls (n = 20)

1 Meniere’s disease (n = 46); 2 Controls (n = 46)

1 Meniere’s disease (n = 734); 2 Controls (n = 172)

1 Meniere’s disease (n = 42); 2 Controls (n = 18)

Derebery 1979 2000 4 Cohort 1 Meniere’s disease treated with AIT and diet (n = 113); 2 Controls (n = 24) Derebery & Valenzuela 1980

control

control

control

control

Evidence for the role of allergic rhinitis in inner ear disease Study Year LOE Singh et al. 1977 2011 3b Case Keles et al. 1981 2004 3b Case Derebery & Berliner 1978 2000 3b Case Hsu et al. 1982 1990 3b Case

ABR = auditory-brainstem response; AIT = allergen immunotherapy; AR = allergic rhinitis; ECoG = electrocochleography; IgE = immunoglobulin E; LOE = level of evidence; OAE = oto-acoustic emissions.

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.