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Wise et al.

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Author Manuscript Author Manuscript Author Manuscript Author Manuscript TABLE X.I.

Evidence for an association between allergic rhinitis and laryngeal disease Study Year LOE Study design Study groups Clinical endpoint Conclusion Roth et al. 2008 2013 2b RCT Patients responding to an advertisement Effect of allergen on larynx Relationship between allergen exposure and impaired vocal function independent of asthma or nasal exposure. Dworkin et al. 2010 2009 2b RCT Adults testing positive for HDM allergy: 1 D. pteronyssinus challenge; 2 Placebo challenge Effect of allergen on larynx Laryngeal abnormalities occurred secondary to lower respiratory stimulation. Krouse et al. 1998 2008 2b Prospective cohort 1 HDM allergy, (+) skin test; 2 No HDM allergy Effect of allergen on larynx Significant changes in VHI in patients with HDM allergy. Findings present among subjects without symptomatic LPR/GERD. Millqvist et al. 1996 2006 2b Case-control 1 Birch pollen allergy; 2 Control Prevalence of vocal dysfunction Statistically significant differences in VHI between allergic patients and controls. Reidy et al. 2009 2003 2b RCT 1 D. pteronyssinus challenge; 2 Placebo challenge Effect of allergen on larynx

No significant differences between antigen and placebo exposed subjects on any measure. and mean VHI.

Roth & Ferguson 1995 2010 3a Systematic review Relationship of allergy and laryngeal disease Not applicable Further investigations into mechanisms mediating laryngeal response to allergy are necessary. Brook et al. 2011 2015 3b Retrospective case-control 1 Atopic patients; 2 Nonatopic patients Endoscopic findings in AR Findings within the nasopharynx, rather than the larynx, are predictive of positive atopic status. Koc et al. 1997 2014 3b Case-control 1 AR patients; 2 Control Turley et al. 2001 2011 3b Case-control 1 Patients with rhinitis symptoms, (+) and (−) allergy tests; 2 Patients without rhinitis Prevalence of dysphonia Patients with AR or NAR had higher prevalence of dysphonia versus controls. Patients with worse Hamdan et al. 2000 2006 3b Retrospective case-control 1 Singers without vocal symptoms; 2 Singers with vocal symptoms Symptom prevalence Incidence of AR in singers is high. Occult allergies may affect professional voice. Brook et al. 2004 2016 4 Retrospective case series Laryngeal findings in AR AR patients had higher incidence of dysphonia rhinitis symptoms had worse voice-related QOL and more severe chronic laryngeal symptoms.

Patients undergoing in vitro allergy testing Symptom prevalence Yield of in vitro allergy testing for laryngeal symptoms comparable to other common allergy testing indications.

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.