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Wise et al.

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Author Manuscript Author Manuscript Author Manuscript Author Manuscript TABLE X.J.

Evidence for the association between allergic rhinitis and eosinophilic esophagitis Study Year LOE Study design Study groups Clinical endpoint Conclusion Evidence of AR prevalence in patients with EoE Furuta et al. 2015 2007 3a Systematic review Adult and pediatric patients with EoE Demographic and clinical characteristics 50% to 80% had AR and sensitization to aeroallergens. Spergel et al. 2013 2009 4 Case series Pediatric patients with EoE (n = 562) Demographic and clinical characteristics 68% were atopic and 43% had AR. Roy-Ghanta et al. 2014 2008 4 Case series Adult patients with EoE (n = 23) Demographic and clinical characteristics 78% had AR; 86% were sensitized to aeroallergens. Assa’ad et al. 2016 2007 4 Case series Pediatric patients with EoE (n = 89) Demographic and clinical characteristics 79% were sensitized to environmental allergens. Plaza-Martin et al. 2017 2007 4 Case series Pediatric patients with EoE in Spain (n = 14) Demographic and clinical characteristics 93% had AR and sensitization to aeroallergens. Sugnanam et al. 2018 2007 4 Case series Pediatric patients with EoE in Australia (n = 45) Demographic and clinical characteristics 93% had AR. Remedios et al. 2019 2006 4 Case series Adult patients with EoE in Australia (n = 26) Demographic and clinical characteristics 77% were atopic and 54% had AR. Guajardo et al. 2020 2002 4 Case series Adult and pediatric patients with EoE in worldwide registry (n = 39) Demographic and clinical characteristics 64% had AR. Eosinophils on esophageal biopsies

Evidence for role of aeroallergens in EoE pathogenesis Ramirez & Jacobs 2025 2013 4 Case report A pediatric patient with EoE and dust mite allergy treated with dust mite immunotherapy Resolution of esophageal eosinophilia was observed after course of dust mite immunotherapy. Moawad et al. 2021 2010 4 Case series Adult patients with EoE (n = 127) Season of EoE diagnosis and correlation with pollen counts

Highest percentage (33%) diagnosed in spring and lowest (16%) in winter; significant correlation with grass pollen counts.

Almansa et al. 2022 2009 4 Case series Adult patients with EoE (n = 41) Season of EoE diagnosis 68% diagnosed in spring and summer vs 32% in fall and winter. Wang et al. 2023 2007 4 Case series Pediatric patients with EoE (n = 234) Season of EoE diagnosis and biopsy findings by season

Significantly fewer patients diagnosed with EoE in winter vs spring, summer, and fall; least intense esophageal eosinophilia in winter.

Fogg et al. 2024 2003 4 Case report Pediatric patient with EoE Seasonal biopsy findings Increased esophageal eosinophilia during pollen seasons.

AR = allergic rhinitis; EoE = eosinophilic esophagitis; LOE = level of evidence.

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.