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Wise et al.

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Author Manuscript Author Manuscript Author Manuscript Author Manuscript TABLE X.K.

Evidence for an association between allergic rhinitis and sleep disturbance Study Year LOE Study design Study groups Clinical endpoint Conclusion Yamada et al. 673 2012 1b RCT PAR, adults (n = 57) ESS and RQLQ INCS mometasone significantly improves nasal symptoms, QOL, sleep quality, and upper airway condition. Meltzer et al. 1276 2010 1b RCT PAR, adults (n = 30) PSG, ESS, RQLQ-S, and WPAI AS INCS mometasone improves nasal symptoms and sleepiness. Craig et al. 1275 2003 1b RCT AR, adults (n = 32) PSG, ESS, RQLQ, direct sleep questions in daily diary Improvement in NC and sleep with treatment with topical nasal fluticasone. Hughes et al. 706 2003 1b RCT PAR, adults (n = 22) ESS, SSS, FOSQ, RQLQ INCS budesonide improved daytime fatigue, somnolence and quality of sleep. Craig et al. 707 1998 1b RCT PAR, adults (n = 20) Direct sleep questions in daily diary Improvement in congestion and sleep with treatment with INCS flunisolide. Sherkat et al. 2030 2011 2b RCT AR, adults (n = 14) ESS, PSQI, FOSQ, RQLQ, NRQLQ, Pennsylvania Quality of Life, direct sleep questions in daily diary

Sleep quality is not significantly affected by pseudoephedrine. AR disrupts the pattern and quality of sleep.

Moderate-severe AR and NC are associated with worse sleep quality.

The severity of the AR has more effect on QOL and sleep, than the duration (intermittent/persistent).

All dimensions of sleep were impaired by AR, and more impaired in severe AR than in mild AR.

Young et al. 714 1997 2c Population-based Adults (n = 4927) PSG, direct sleep questions Moderate-to-severe SDB was 1.8 times more frequent in participants with NC due to allergy. Ishman et al. 2034 2012 3b Case-control AR, children (n = 21) PSQ, PDSS, Obstructive Sleep Apnea-18 AR children have higher SDB and sleepiness scores.

Meng et al. 720 2011 3b Case-control PAR, adults (n = 98) PSG Differences in most PSG parameters including sleep efficiency, arousal index, and snoring time, statistically significant (though clinically modest).

Benninger & Benninger 2036 2009 3b Case-control AR, adults (n = 701) RSDI and sleep question by RSDI AR has a significant negative impact on sexual function, sleep, and fatigue. Meltzer et al. 2037 2009 3b Case-control AR, adults (n = 7024) MOS-Sleep and mini-RQLQ AR adversely affects QOL and sleep parameters.

Yuksel et al. 2035 2009 3b Case-control SAR, children (n = 14) PSQI and actigraphy Sleep dysfunction scores, sleep latency and fragmentation index are significantly higher in the AR group.

Colas et al. 726 2012 2c Population-based AR, adults (n = 2275) PSQI RQLQ, direct sleep questions based on Epworth scale

Meltzer et al. 2027 2009 2c Population-based AR, children (n = 1004) Direct sleep questions by telephone interviews Bousquet et al. 2028 2006 2c Population-based AR, adults (n = 3052) Jenkins Questionnaire, RQLQ, WPAI-AS Leger et al. 727 2006 2c Population-based AR, adults (n = 591) ESS, Sleep Disorders Questionnaire, Score for Allergic Rhinitis

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.